TC4 more effective in the PI3K+ biomarker signature
| signature | var | Other | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|---|
| all | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.02, shape = 1.3 |
| all | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 39, median = 31.9 | mean = 46.8, median = 38.2 |
| all | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1, hr = 1 | af = 1.2, hr = 0.79 |
| HRD+ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.022, shape = 1.3 |
| HRD+ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 39, median = 31.9 | mean = 42.7, median = 34.9 |
| HRD+ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1, hr = 1 | af = 1.09, hr = 0.89 |
| TP53+ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.019, shape = 1.3 |
| TP53+ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 39, median = 31.9 | mean = 49.2, median = 40.2 |
| TP53+ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1, hr = 1 | af = 1.26, hr = 0.74 |
| TEfus+ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.018, shape = 1.3 |
| TEfus+ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 39, median = 31.9 | mean = 52.7, median = 43 |
| TEfus+ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1, hr = 1 | af = 1.35, hr = 0.68 |
| PI3K+ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.012, shape = 1.3 |
| PI3K+ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 39, median = 31.9 | mean = 78.1, median = 63.8 |
| PI3K+ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1, hr = 1 | af = 2, hr = 0.41 |
| subtype | var | Other | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|---|
| —- | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| —- | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| —- | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1, hr = 1 | af = 1, hr = 1 |
| —+ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.012, shape = 1.3 |
| —+ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 39, median = 31.9 | mean = 78.1, median = 63.8 |
| —+ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1, hr = 1 | af = 2, hr = 0.41 |
| –+- | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| –+- | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| –+- | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1, hr = 1 | af = 1, hr = 1 |
| –++ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.012, shape = 1.3 |
| –++ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 39, median = 31.9 | mean = 78.1, median = 63.8 |
| –++ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1, hr = 1 | af = 2, hr = 0.41 |
| -+– | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| -+– | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| -+– | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1, hr = 1 | af = 1, hr = 1 |
| -+-+ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.012, shape = 1.3 |
| -+-+ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 39, median = 31.9 | mean = 78.1, median = 63.8 |
| -+-+ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1, hr = 1 | af = 2, hr = 0.41 |
| -++- | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| -++- | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| -++- | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1, hr = 1 | af = 1, hr = 1 |
| -+++ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.012, shape = 1.3 |
| -+++ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 39, median = 31.9 | mean = 78.1, median = 63.8 |
| -+++ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1, hr = 1 | af = 2, hr = 0.41 |
| +— | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| +— | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| +— | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1, hr = 1 | af = 1, hr = 1 |
| +–+ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.012, shape = 1.3 |
| +–+ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 39, median = 31.9 | mean = 78.1, median = 63.8 |
| +–+ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1, hr = 1 | af = 2, hr = 0.41 |
| +-+- | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| +-+- | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| +-+- | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1, hr = 1 | af = 1, hr = 1 |
| +-++ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.012, shape = 1.3 |
| +-++ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 39, median = 31.9 | mean = 78.1, median = 63.8 |
| +-++ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1, hr = 1 | af = 2, hr = 0.41 |
| ++– | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| ++– | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| ++– | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1, hr = 1 | af = 1, hr = 1 |
| ++-+ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.012, shape = 1.3 |
| ++-+ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 39, median = 31.9 | mean = 78.1, median = 63.8 |
| ++-+ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1, hr = 1 | af = 2, hr = 0.41 |
| +++- | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| +++- | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| +++- | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1, hr = 1 | af = 1, hr = 1 |
| ++++ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.012, shape = 1.3 |
| ++++ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 39, median = 31.9 | mean = 78.1, median = 63.8 |
| ++++ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1, hr = 1 | af = 2, hr = 0.41 |
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| Characteristics | Overall | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|
| Error signature | 0.376 | 0.03 | 0.046 | 0.184 | 0.184 |
| Error subgroup | 0.728 | 0.03 | 0.046 | 0.184 | 0.620 |
| Power signature | 0.754 | 0.00 | 0.000 | 0.000 | 0.754 |
| Power subgroup | 0.938 | 0.00 | 0.000 | 0.000 | 0.938 |
| signature | var | Control | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|---|
| all | graduation | 0 | 1 | 4 | 25 | 129 |
| all | futility | 0 | 19 | 24 | 2 | 0 |
| all | max_n | 0 | 0 | 0 | 0 | 0 |
| all | n | 627 (577, 690) | 261 (181, 371) | 274 (182, 366) | 366 (240, 468) | 266 (88, 397) |
| all | n_unique | 627 (577, 690) | 261 (181, 371) | 274 (182, 366) | 366 (240, 468) | 266 (88, 397) |
| all | time_trial | 60 (60, 60) | 60 (60, 60) | 60 (60, 60) | 60 (60, 60) | 60 (17, 60) |
| all | time_stop | NA (NA, NA) | 34 (18, 52) | 32 (12, 56) | 15 (11, 33) | 20 (12, 50) |
| all | post_p | NA (NA, NA) | 0.26 (0.03, 0.74) | 0.31 (0.04, 0.76) | 0.86 (0.42, 0.99) | 1 (1, 1) |
| all | rate | 0.023 (0.022, 0.025) | 0.025 (0.023, 0.028) | 0.025 (0.022, 0.028) | 0.021 (0.019, 0.023) | 0.016 (0.014, 0.018) |
| HRD+ | graduation | 0 | 9 | 14 | 28 | 37 |
| HRD+ | futility | 0 | 12 | 8 | 9 | 0 |
| HRD+ | max_n | 0 | 0 | 0 | 0 | 0 |
| HRD+ | n | 85 (72, 100) | 42 (27, 61) | 41 (25, 61) | 52 (32, 72) | 38 (11, 56) |
| HRD+ | n_unique | 85 (72, 100) | 42 (27, 61) | 41 (25, 61) | 52 (32, 72) | 38 (11, 56) |
| HRD+ | time_trial | 60 (60, 60) | 60 (60, 60) | 60 (60, 60) | 60 (60, 60) | 60 (60, 60) |
| HRD+ | time_stop | NA (NA, NA) | 52 (39, 58) | 52 (47, 57) | 51 (39, 57) | 51 (45, 57) |
| HRD+ | post_p | NA (NA, NA) | 0.41 (0.09, 0.79) | 0.41 (0.08, 0.82) | 0.64 (0.18, 0.94) | 0.82 (0.37, 0.98) |
| HRD+ | rate | 0.023 (0.019, 0.028) | 0.025 (0.019, 0.033) | 0.025 (0.019, 0.033) | 0.022 (0.017, 0.028) | 0.018 (0.012, 0.025) |
| TP53+ | graduation | 0 | 5 | 4 | 26 | 147 |
| TP53+ | futility | 0 | 139 | 166 | 37 | 0 |
| TP53+ | max_n | 0 | 0 | 0 | 0 | 0 |
| TP53+ | n | 236 (209, 265) | 100 (54, 156) | 98 (52, 153) | 131 (70, 192) | 89 (36, 150) |
| TP53+ | n_unique | 236 (209, 265) | 100 (54, 156) | 98 (52, 153) | 131 (70, 192) | 89 (36, 150) |
| TP53+ | time_trial | 60 (60, 60) | 60 (35, 60) | 60 (27, 60) | 60 (49, 60) | 60 (32, 60) |
| TP53+ | time_stop | NA (NA, NA) | 39 (27, 55) | 33 (22, 51) | 40 (26, 53) | 36 (26, 55) |
| TP53+ | post_p | NA (NA, NA) | 0.34 (0.06, 0.76) | 0.34 (0.05, 0.78) | 0.74 (0.28, 0.96) | 1 (0.94, 1) |
| TP53+ | rate | 0.023 (0.02, 0.026) | 0.025 (0.021, 0.031) | 0.025 (0.021, 0.031) | 0.021 (0.018, 0.025) | 0.015 (0.012, 0.018) |
| TEfus+ | graduation | 0 | 0 | 1 | 14 | 109 |
| TEfus+ | futility | 0 | 96 | 90 | 31 | 0 |
| TEfus+ | max_n | 0 | 0 | 0 | 0 | 0 |
| TEfus+ | n | 203 (179, 232) | 88 (53, 133) | 92 (52, 138) | 114 (64, 161) | 80 (30, 129) |
| TEfus+ | n_unique | 203 (179, 232) | 88 (53, 133) | 92 (52, 138) | 114 (64, 161) | 80 (30, 129) |
| TEfus+ | time_trial | 60 (60, 60) | 60 (45, 60) | 60 (43, 60) | 60 (60, 60) | 60 (35, 60) |
| TEfus+ | time_stop | NA (NA, NA) | 45 (32, 56) | 40 (27, 59) | 45 (32, 57) | 36 (24, 55) |
| TEfus+ | post_p | NA (NA, NA) | 0.33 (0.04, 0.74) | 0.35 (0.05, 0.81) | 0.69 (0.23, 0.97) | 1 (0.96, 1) |
| TEfus+ | rate | 0.023 (0.02, 0.026) | 0.025 (0.021, 0.031) | 0.025 (0.021, 0.031) | 0.021 (0.017, 0.025) | 0.013 (0.011, 0.017) |
| PI3K+ | graduation | 0 | 1 | 2 | 9 | 377 |
| PI3K+ | futility | 0 | 144 | 119 | 45 | 0 |
| PI3K+ | max_n | 0 | 0 | 0 | 0 | 0 |
| PI3K+ | n | 222 (196, 248) | 88 (53, 145) | 91 (52, 140) | 123 (63, 179) | 90 (42, 157) |
| PI3K+ | n_unique | 222 (196, 248) | 88 (53, 145) | 91 (52, 140) | 123 (63, 179) | 90 (42, 157) |
| PI3K+ | time_trial | 60 (60, 60) | 60 (37, 60) | 60 (39, 60) | 60 (57, 60) | 40 (27, 60) |
| PI3K+ | time_stop | NA (NA, NA) | 42 (32, 54) | 42 (28, 56) | 39 (29, 56) | 36 (26, 50) |
| PI3K+ | post_p | NA (NA, NA) | 0.3 (0.05, 0.75) | 0.34 (0.05, 0.8) | 0.71 (0.23, 0.95) | 1 (1, 1) |
| PI3K+ | rate | 0.023 (0.02, 0.026) | 0.025 (0.021, 0.031) | 0.025 (0.021, 0.03) | 0.021 (0.018, 0.025) | 0.009 (0.007, 0.012) |
| subtype | var | Control | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|---|
| —- | graduation | 0 | 1 | 4 | 25 | 129 |
| —- | futility | 0 | 19 | 24 | 2 | 0 |
| —- | max_n | 0 | 0 | 0 | 0 | 0 |
| —- | n | 191 (159, 227) | 62 (28, 143) | 67 (26, 154) | 114 (31, 185) | 74 (19, 168) |
| —- | n_unique | 191 (159, 227) | 62 (28, 143) | 67 (26, 154) | 114 (31, 185) | 74 (19, 168) |
| —- | post_p | NA (NA, NA) | 0.33 (0.07, 0.77) | 0.38 (0.07, 0.81) | 0.72 (0.21, 0.97) | 0.65 (0.2, 0.96) |
| —- | rate | 0.023 (0.02, 0.026) | 0.026 (0.021, 0.034) | 0.026 (0.021, 0.034) | 0.021 (0.017, 0.028) | 0.022 (0.017, 0.03) |
| —+ | graduation | 0 | 2 | 6 | 32 | 449 |
| —+ | futility | 0 | 152 | 131 | 47 | 0 |
| —+ | max_n | 0 | 0 | 0 | 0 | 0 |
| —+ | n | 45 (35, 55) | 16 (8, 37) | 16 (7, 37) | 23 (8, 45) | 18 (8, 37) |
| —+ | n_unique | 45 (35, 55) | 16 (8, 37) | 16 (7, 37) | 23 (8, 45) | 18 (8, 37) |
| —+ | post_p | NA (NA, NA) | 0.33 (0.08, 0.76) | 0.36 (0.09, 0.77) | 0.54 (0.16, 0.88) | 0.98 (0.8, 1) |
| —+ | rate | 0.023 (0.017, 0.03) | 0.027 (0.018, 0.043) | 0.026 (0.017, 0.042) | 0.021 (0.014, 0.035) | 0.009 (0.004, 0.015) |
| –+- | graduation | 0 | 1 | 5 | 39 | 209 |
| –+- | futility | 0 | 106 | 104 | 32 | 0 |
| –+- | max_n | 0 | 0 | 0 | 0 | 0 |
| –+- | n | 13 (8, 18) | 7 (3, 13) | 7 (3, 13) | 7 (3, 13) | 5 (1, 11) |
| –+- | n_unique | 13 (8, 18) | 7 (3, 13) | 7 (3, 13) | 7 (3, 13) | 5 (1, 11) |
| –+- | post_p | NA (NA, NA) | 0.45 (0.19, 0.77) | 0.43 (0.17, 0.76) | 0.53 (0.24, 0.83) | 0.54 (0.25, 0.81) |
| –+- | rate | 0.023 (0.012, 0.036) | 0.026 (0.011, 0.052) | 0.026 (0.013, 0.052) | 0.022 (0.007, 0.046) | 0.021 (0.006, 0.049) |
| –++ | graduation | 0 | 2 | 7 | 46 | 457 |
| –++ | futility | 0 | 196 | 182 | 71 | 0 |
| –++ | max_n | 0 | 0 | 0 | 0 | 0 |
| –++ | n | 67 (54, 82) | 21 (10, 54) | 21 (11, 53) | 35 (10, 63) | 27 (10, 51) |
| –++ | n_unique | 67 (54, 82) | 21 (10, 54) | 21 (11, 53) | 35 (10, 63) | 27 (10, 51) |
| –++ | post_p | NA (NA, NA) | 0.35 (0.07, 0.74) | 0.33 (0.08, 0.78) | 0.54 (0.14, 0.89) | 0.99 (0.9, 1) |
| –++ | rate | 0.023 (0.019, 0.028) | 0.026 (0.019, 0.039) | 0.026 (0.018, 0.039) | 0.021 (0.015, 0.033) | 0.01 (0.006, 0.014) |
| -+– | graduation | 0 | 6 | 7 | 50 | 247 |
| -+– | futility | 0 | 147 | 176 | 38 | 0 |
| -+– | max_n | 0 | 0 | 0 | 0 | 0 |
| -+– | n | 82 (66, 99) | 29 (13, 73) | 30 (15, 67) | 45 (16, 78) | 26 (9, 64) |
| -+– | n_unique | 82 (66, 99) | 29 (13, 73) | 30 (15, 67) | 45 (16, 78) | 26 (9, 64) |
| -+– | post_p | NA (NA, NA) | 0.42 (0.09, 0.83) | 0.37 (0.09, 0.82) | 0.63 (0.15, 0.94) | 0.65 (0.2, 0.93) |
| -+– | rate | 0.023 (0.019, 0.028) | 0.026 (0.019, 0.038) | 0.027 (0.02, 0.036) | 0.021 (0.016, 0.032) | 0.022 (0.015, 0.033) |
| -+-+ | graduation | 0 | 6 | 8 | 55 | 463 |
| -+-+ | futility | 0 | 225 | 236 | 73 | 0 |
| -+-+ | max_n | 0 | 0 | 0 | 0 | 0 |
| -+-+ | n | 56 (43, 68) | 18 (8, 46) | 18 (8, 45) | 27 (9, 54) | 21 (9, 44) |
| -+-+ | n_unique | 56 (43, 68) | 18 (8, 46) | 18 (8, 45) | 27 (9, 54) | 21 (9, 44) |
| -+-+ | post_p | NA (NA, NA) | 0.34 (0.08, 0.73) | 0.35 (0.07, 0.78) | 0.54 (0.17, 0.89) | 0.98 (0.86, 1) |
| -+-+ | rate | 0.023 (0.018, 0.03) | 0.026 (0.019, 0.041) | 0.027 (0.018, 0.04) | 0.021 (0.014, 0.033) | 0.009 (0.005, 0.015) |
| -++- | graduation | 0 | 6 | 8 | 62 | 288 |
| -++- | futility | 0 | 200 | 221 | 63 | 0 |
| -++- | max_n | 0 | 0 | 0 | 0 | 0 |
| -++- | n | 50 (38, 61) | 19 (8, 42) | 19 (9, 45) | 26 (9, 48) | 14 (5, 32) |
| -++- | n_unique | 50 (38, 61) | 19 (8, 42) | 19 (9, 45) | 26 (9, 48) | 14 (5, 32) |
| -++- | post_p | NA (NA, NA) | 0.41 (0.1, 0.8) | 0.43 (0.1, 0.83) | 0.6 (0.18, 0.91) | 0.56 (0.17, 0.88) |
| -++- | rate | 0.022 (0.017, 0.029) | 0.026 (0.017, 0.042) | 0.026 (0.018, 0.04) | 0.022 (0.014, 0.033) | 0.022 (0.014, 0.037) |
| -+++ | graduation | 0 | 6 | 9 | 67 | 467 |
| -+++ | futility | 0 | 259 | 269 | 93 | 0 |
| -+++ | max_n | 0 | 0 | 0 | 0 | 0 |
| -+++ | n | 38 (29, 48) | 13 (6, 31) | 13 (6, 33) | 21 (7, 38) | 14 (6, 28) |
| -+++ | n_unique | 38 (29, 48) | 13 (6, 31) | 13 (6, 33) | 21 (7, 38) | 14 (6, 28) |
| -+++ | post_p | NA (NA, NA) | 0.34 (0.07, 0.71) | 0.38 (0.1, 0.75) | 0.56 (0.17, 0.87) | 0.95 (0.71, 1) |
| -+++ | rate | 0.022 (0.016, 0.031) | 0.027 (0.017, 0.042) | 0.026 (0.017, 0.042) | 0.02 (0.013, 0.035) | 0.01 (0.004, 0.017) |
| +— | graduation | 0 | 10 | 18 | 53 | 160 |
| +— | futility | 0 | 31 | 32 | 11 | 0 |
| +— | max_n | 0 | 0 | 0 | 0 | 0 |
| +— | n | 40 (31, 51) | 18 (8, 35) | 18 (7, 33) | 22 (10, 40) | 17 (4, 34) |
| +— | n_unique | 40 (31, 51) | 18 (8, 35) | 18 (7, 33) | 22 (10, 40) | 17 (4, 34) |
| +— | post_p | NA (NA, NA) | 0.44 (0.13, 0.82) | 0.4 (0.11, 0.82) | 0.56 (0.17, 0.93) | 0.57 (0.19, 0.9) |
| +— | rate | 0.023 (0.017, 0.031) | 0.025 (0.016, 0.041) | 0.026 (0.017, 0.044) | 0.022 (0.015, 0.035) | 0.022 (0.013, 0.037) |
| +–+ | graduation | 0 | 10 | 20 | 59 | 451 |
| +–+ | futility | 0 | 160 | 135 | 53 | 0 |
| +–+ | max_n | 0 | 0 | 0 | 0 | 0 |
| +–+ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +–+ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +–+ | post_p | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| +–+ | rate | 0.03 (0.006, 0.045) | 0 (0, 0) | 0.085 (0.085, 0.085) | 0 (0, 0) | 0.015 (0.003, 0.026) |
| +-+- | graduation | 0 | 10 | 19 | 66 | 234 |
| +-+- | futility | 0 | 116 | 110 | 41 | 0 |
| +-+- | max_n | 0 | 0 | 0 | 0 | 0 |
| +-+- | n | 29 (22, 37) | 12 (6, 24) | 12 (5, 26) | 17 (7, 30) | 10 (3, 23) |
| +-+- | n_unique | 29 (22, 37) | 12 (6, 24) | 12 (5, 26) | 17 (7, 30) | 10 (3, 23) |
| +-+- | post_p | NA (NA, NA) | 0.41 (0.11, 0.77) | 0.45 (0.13, 0.82) | 0.58 (0.19, 0.9) | 0.56 (0.19, 0.88) |
| +-+- | rate | 0.023 (0.016, 0.033) | 0.027 (0.016, 0.047) | 0.025 (0.015, 0.044) | 0.022 (0.014, 0.037) | 0.022 (0.012, 0.042) |
| +-++ | graduation | 0 | 10 | 21 | 72 | 459 |
| +-++ | futility | 0 | 204 | 184 | 77 | 0 |
| +-++ | max_n | 0 | 0 | 0 | 0 | 0 |
| +-++ | n | 6 (3, 10) | 4 (1, 7) | 4 (1, 7) | 4 (1, 8) | 2 (0, 5) |
| +-++ | n_unique | 6 (3, 10) | 4 (1, 7) | 4 (1, 7) | 4 (1, 8) | 2 (0, 5) |
| +-++ | post_p | NA (NA, NA) | 0.46 (0.3, 0.66) | 0.48 (0.3, 0.65) | 0.47 (0.29, 0.67) | 0.6 (0.46, 0.77) |
| +-++ | rate | 0.023 (0.006, 0.049) | 0.025 (0.006, 0.071) | 0.024 (0, 0.071) | 0.022 (0.006, 0.061) | 0.007 (0, 0.024) |
| ++– | graduation | 0 | 13 | 20 | 75 | 273 |
| ++– | futility | 0 | 155 | 178 | 46 | 0 |
| ++– | max_n | 0 | 0 | 0 | 0 | 0 |
| ++– | n | 1 (0, 3) | 1 (0, 2) | 0 (0, 2) | 1 (0, 2) | 0 (0, 2) |
| ++– | n_unique | 1 (0, 3) | 1 (0, 2) | 0 (0, 2) | 1 (0, 2) | 0 (0, 2) |
| ++– | post_p | NA (NA, NA) | 0.5 (0.43, 0.56) | 0.5 (0.44, 0.57) | 0.49 (0.41, 0.57) | 0.5 (0.43, 0.57) |
| ++– | rate | 0.021 (0, 0.101) | 0.022 (0, 0.113) | 0.024 (0, 0.112) | 0.023 (0, 0.111) | 0.017 (0, 0.096) |
| ++-+ | graduation | 0 | 13 | 21 | 79 | 465 |
| ++-+ | futility | 0 | 231 | 236 | 79 | 0 |
| ++-+ | max_n | 0 | 0 | 0 | 0 | 0 |
| ++-+ | n | 8 (5, 13) | 5 (2, 9) | 4 (1, 9) | 5 (2, 10) | 3 (1, 7) |
| ++-+ | n_unique | 8 (5, 13) | 5 (2, 9) | 4 (1, 9) | 5 (2, 10) | 3 (1, 7) |
| ++-+ | post_p | NA (NA, NA) | 0.44 (0.23, 0.67) | 0.45 (0.26, 0.69) | 0.48 (0.26, 0.72) | 0.62 (0.45, 0.84) |
| ++-+ | rate | 0.023 (0.01, 0.043) | 0.026 (0.008, 0.066) | 0.025 (0.008, 0.062) | 0.022 (0.009, 0.054) | 0.009 (0, 0.026) |
| +++- | graduation | 0 | 13 | 21 | 87 | 310 |
| +++- | futility | 0 | 207 | 222 | 71 | 0 |
| +++- | max_n | 0 | 0 | 0 | 0 | 0 |
| +++- | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +++- | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +++- | post_p | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.47 (0.47, 0.48) | NA (NA, NA) |
| +++- | rate | 0.028 (0.006, 0.035) | 0 (0, 0.023) | NA (NA, NA) | 0.087 (0, 0.157) | 0.027 (0.023, 0.031) |
| ++++ | graduation | 0 | 13 | 22 | 91 | 469 |
| ++++ | futility | 0 | 265 | 268 | 99 | 0 |
| ++++ | max_n | 0 | 0 | 0 | 0 | 0 |
| ++++ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++++ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++++ | post_p | NA (NA, NA) | NA (NA, NA) | 0.45 (0.45, 0.45) | 0.44 (0.44, 0.44) | 0.52 (0.52, 0.52) |
| ++++ | rate | 0 (0, 0.323) | 0.041 (0, 0.112) | 0.02 (0, 0.069) | 0 (0, 0.155) | 0 (0, 0.113) |
Posterior probabilities
Randomization probabilities
PFS rates
Posterior probabilities
Randomization probabilities