Setting description

TC4 more effective in the PI3K+ biomarker signature

Simulations setting

Survival curves (by signature)


PFS distributions (by signature)


Treatment effects (by signature)

signature var Other TC1 TC2 TC3 TC4
all param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.02, shape = 1.3
all summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 46.8, median = 38.2
all effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 1.2, hr = 0.79
HRD+ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.022, shape = 1.3
HRD+ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 42.7, median = 34.9
HRD+ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 1.09, hr = 0.89
TP53+ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.019, shape = 1.3
TP53+ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 49.2, median = 40.2
TP53+ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 1.26, hr = 0.74
TEfus+ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.018, shape = 1.3
TEfus+ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 52.7, median = 43
TEfus+ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 1.35, hr = 0.68
PI3K+ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.012, shape = 1.3
PI3K+ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 78.1, median = 63.8
PI3K+ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 2, hr = 0.41



Survival curves (by subgroup)


PFS distributions (by subgroup)


Treatment effects (by subgroup)

subtype var Other TC1 TC2 TC3 TC4
—- param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
—- summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 39, median = 31.9
—- effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 1, hr = 1
—+ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.012, shape = 1.3
—+ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 78.1, median = 63.8
—+ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 2, hr = 0.41
–+- param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
–+- summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 39, median = 31.9
–+- effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 1, hr = 1
–++ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.012, shape = 1.3
–++ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 78.1, median = 63.8
–++ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 2, hr = 0.41
-+– param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
-+– summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 39, median = 31.9
-+– effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 1, hr = 1
-+-+ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.012, shape = 1.3
-+-+ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 78.1, median = 63.8
-+-+ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 2, hr = 0.41
-++- param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
-++- summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 39, median = 31.9
-++- effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 1, hr = 1
-+++ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.012, shape = 1.3
-+++ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 78.1, median = 63.8
-+++ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 2, hr = 0.41
+— param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
+— summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 39, median = 31.9
+— effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 1, hr = 1
+–+ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.012, shape = 1.3
+–+ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 78.1, median = 63.8
+–+ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 2, hr = 0.41
+-+- param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
+-+- summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 39, median = 31.9
+-+- effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 1, hr = 1
+-++ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.012, shape = 1.3
+-++ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 78.1, median = 63.8
+-++ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 2, hr = 0.41
++– param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
++– summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 39, median = 31.9
++– effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 1, hr = 1
++-+ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.012, shape = 1.3
++-+ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 78.1, median = 63.8
++-+ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 2, hr = 0.41
+++- param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
+++- summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 39, median = 31.9
+++- effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 1, hr = 1
++++ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.012, shape = 1.3
++++ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 78.1, median = 63.8
++++ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 2, hr = 0.41

Errors and power


graduation (counts and proportions):
TC1 TC2 TC3 TC4
all 1 4 25 129
HRD+ 9 14 28 37
TP53+ 5 4 26 147
TEfus+ 0 1 14 109
PI3K+ 1 2 9 377
TC1 TC2 TC3 TC4
all 0.002 0.008 0.050 0.258
HRD+ 0.018 0.028 0.056 0.074
TP53+ 0.010 0.008 0.052 0.294
TEfus+ 0.000 0.002 0.028 0.218
PI3K+ 0.002 0.004 0.018 0.754
futility (counts and proportions):
TC1 TC2 TC3 TC4
all 19 24 2 0
HRD+ 12 8 9 0
TP53+ 139 166 37 0
TEfus+ 96 90 31 0
PI3K+ 144 119 45 0
TC1 TC2 TC3 TC4
all 0.038 0.048 0.004 0
HRD+ 0.024 0.016 0.018 0
TP53+ 0.278 0.332 0.074 0
TEfus+ 0.192 0.180 0.062 0
PI3K+ 0.288 0.238 0.090 0
max sample size (counts and proportions):
TC1 TC2 TC3 TC4
all 0 0 0 0
HRD+ 0 0 0 0
TP53+ 0 0 0 0
TEfus+ 0 0 0 0
PI3K+ 0 0 0 0
TC1 TC2 TC3 TC4
all 0 0 0 0
HRD+ 0 0 0 0
TP53+ 0 0 0 0
TEfus+ 0 0 0 0
PI3K+ 0 0 0 0


Operating characteristics

Characteristics Overall TC1 TC2 TC3 TC4
Error signature 0.376 0.03 0.046 0.184 0.184
Error subgroup 0.728 0.03 0.046 0.184 0.620
Power signature 0.754 0.00 0.000 0.000 0.754
Power subgroup 0.938 0.00 0.000 0.000 0.938

Median results at the end of the trial

By signature:
signature var Control TC1 TC2 TC3 TC4
all graduation 0 1 4 25 129
all futility 0 19 24 2 0
all max_n 0 0 0 0 0
all n 627 (577, 690) 261 (181, 371) 274 (182, 366) 366 (240, 468) 266 (88, 397)
all n_unique 627 (577, 690) 261 (181, 371) 274 (182, 366) 366 (240, 468) 266 (88, 397)
all time_trial 60 (60, 60) 60 (60, 60) 60 (60, 60) 60 (60, 60) 60 (17, 60)
all time_stop NA (NA, NA) 34 (18, 52) 32 (12, 56) 15 (11, 33) 20 (12, 50)
all post_p NA (NA, NA) 0.26 (0.03, 0.74) 0.31 (0.04, 0.76) 0.86 (0.42, 0.99) 1 (1, 1)
all rate 0.023 (0.022, 0.025) 0.025 (0.023, 0.028) 0.025 (0.022, 0.028) 0.021 (0.019, 0.023) 0.016 (0.014, 0.018)
HRD+ graduation 0 9 14 28 37
HRD+ futility 0 12 8 9 0
HRD+ max_n 0 0 0 0 0
HRD+ n 85 (72, 100) 42 (27, 61) 41 (25, 61) 52 (32, 72) 38 (11, 56)
HRD+ n_unique 85 (72, 100) 42 (27, 61) 41 (25, 61) 52 (32, 72) 38 (11, 56)
HRD+ time_trial 60 (60, 60) 60 (60, 60) 60 (60, 60) 60 (60, 60) 60 (60, 60)
HRD+ time_stop NA (NA, NA) 52 (39, 58) 52 (47, 57) 51 (39, 57) 51 (45, 57)
HRD+ post_p NA (NA, NA) 0.41 (0.09, 0.79) 0.41 (0.08, 0.82) 0.64 (0.18, 0.94) 0.82 (0.37, 0.98)
HRD+ rate 0.023 (0.019, 0.028) 0.025 (0.019, 0.033) 0.025 (0.019, 0.033) 0.022 (0.017, 0.028) 0.018 (0.012, 0.025)
TP53+ graduation 0 5 4 26 147
TP53+ futility 0 139 166 37 0
TP53+ max_n 0 0 0 0 0
TP53+ n 236 (209, 265) 100 (54, 156) 98 (52, 153) 131 (70, 192) 89 (36, 150)
TP53+ n_unique 236 (209, 265) 100 (54, 156) 98 (52, 153) 131 (70, 192) 89 (36, 150)
TP53+ time_trial 60 (60, 60) 60 (35, 60) 60 (27, 60) 60 (49, 60) 60 (32, 60)
TP53+ time_stop NA (NA, NA) 39 (27, 55) 33 (22, 51) 40 (26, 53) 36 (26, 55)
TP53+ post_p NA (NA, NA) 0.34 (0.06, 0.76) 0.34 (0.05, 0.78) 0.74 (0.28, 0.96) 1 (0.94, 1)
TP53+ rate 0.023 (0.02, 0.026) 0.025 (0.021, 0.031) 0.025 (0.021, 0.031) 0.021 (0.018, 0.025) 0.015 (0.012, 0.018)
TEfus+ graduation 0 0 1 14 109
TEfus+ futility 0 96 90 31 0
TEfus+ max_n 0 0 0 0 0
TEfus+ n 203 (179, 232) 88 (53, 133) 92 (52, 138) 114 (64, 161) 80 (30, 129)
TEfus+ n_unique 203 (179, 232) 88 (53, 133) 92 (52, 138) 114 (64, 161) 80 (30, 129)
TEfus+ time_trial 60 (60, 60) 60 (45, 60) 60 (43, 60) 60 (60, 60) 60 (35, 60)
TEfus+ time_stop NA (NA, NA) 45 (32, 56) 40 (27, 59) 45 (32, 57) 36 (24, 55)
TEfus+ post_p NA (NA, NA) 0.33 (0.04, 0.74) 0.35 (0.05, 0.81) 0.69 (0.23, 0.97) 1 (0.96, 1)
TEfus+ rate 0.023 (0.02, 0.026) 0.025 (0.021, 0.031) 0.025 (0.021, 0.031) 0.021 (0.017, 0.025) 0.013 (0.011, 0.017)
PI3K+ graduation 0 1 2 9 377
PI3K+ futility 0 144 119 45 0
PI3K+ max_n 0 0 0 0 0
PI3K+ n 222 (196, 248) 88 (53, 145) 91 (52, 140) 123 (63, 179) 90 (42, 157)
PI3K+ n_unique 222 (196, 248) 88 (53, 145) 91 (52, 140) 123 (63, 179) 90 (42, 157)
PI3K+ time_trial 60 (60, 60) 60 (37, 60) 60 (39, 60) 60 (57, 60) 40 (27, 60)
PI3K+ time_stop NA (NA, NA) 42 (32, 54) 42 (28, 56) 39 (29, 56) 36 (26, 50)
PI3K+ post_p NA (NA, NA) 0.3 (0.05, 0.75) 0.34 (0.05, 0.8) 0.71 (0.23, 0.95) 1 (1, 1)
PI3K+ rate 0.023 (0.02, 0.026) 0.025 (0.021, 0.031) 0.025 (0.021, 0.03) 0.021 (0.018, 0.025) 0.009 (0.007, 0.012)


By subgroup combinations:
subtype var Control TC1 TC2 TC3 TC4
—- graduation 0 1 4 25 129
—- futility 0 19 24 2 0
—- max_n 0 0 0 0 0
—- n 191 (159, 227) 62 (28, 143) 67 (26, 154) 114 (31, 185) 74 (19, 168)
—- n_unique 191 (159, 227) 62 (28, 143) 67 (26, 154) 114 (31, 185) 74 (19, 168)
—- post_p NA (NA, NA) 0.33 (0.07, 0.77) 0.38 (0.07, 0.81) 0.72 (0.21, 0.97) 0.65 (0.2, 0.96)
—- rate 0.023 (0.02, 0.026) 0.026 (0.021, 0.034) 0.026 (0.021, 0.034) 0.021 (0.017, 0.028) 0.022 (0.017, 0.03)
—+ graduation 0 2 6 32 449
—+ futility 0 152 131 47 0
—+ max_n 0 0 0 0 0
—+ n 45 (35, 55) 16 (8, 37) 16 (7, 37) 23 (8, 45) 18 (8, 37)
—+ n_unique 45 (35, 55) 16 (8, 37) 16 (7, 37) 23 (8, 45) 18 (8, 37)
—+ post_p NA (NA, NA) 0.33 (0.08, 0.76) 0.36 (0.09, 0.77) 0.54 (0.16, 0.88) 0.98 (0.8, 1)
—+ rate 0.023 (0.017, 0.03) 0.027 (0.018, 0.043) 0.026 (0.017, 0.042) 0.021 (0.014, 0.035) 0.009 (0.004, 0.015)
–+- graduation 0 1 5 39 209
–+- futility 0 106 104 32 0
–+- max_n 0 0 0 0 0
–+- n 13 (8, 18) 7 (3, 13) 7 (3, 13) 7 (3, 13) 5 (1, 11)
–+- n_unique 13 (8, 18) 7 (3, 13) 7 (3, 13) 7 (3, 13) 5 (1, 11)
–+- post_p NA (NA, NA) 0.45 (0.19, 0.77) 0.43 (0.17, 0.76) 0.53 (0.24, 0.83) 0.54 (0.25, 0.81)
–+- rate 0.023 (0.012, 0.036) 0.026 (0.011, 0.052) 0.026 (0.013, 0.052) 0.022 (0.007, 0.046) 0.021 (0.006, 0.049)
–++ graduation 0 2 7 46 457
–++ futility 0 196 182 71 0
–++ max_n 0 0 0 0 0
–++ n 67 (54, 82) 21 (10, 54) 21 (11, 53) 35 (10, 63) 27 (10, 51)
–++ n_unique 67 (54, 82) 21 (10, 54) 21 (11, 53) 35 (10, 63) 27 (10, 51)
–++ post_p NA (NA, NA) 0.35 (0.07, 0.74) 0.33 (0.08, 0.78) 0.54 (0.14, 0.89) 0.99 (0.9, 1)
–++ rate 0.023 (0.019, 0.028) 0.026 (0.019, 0.039) 0.026 (0.018, 0.039) 0.021 (0.015, 0.033) 0.01 (0.006, 0.014)
-+– graduation 0 6 7 50 247
-+– futility 0 147 176 38 0
-+– max_n 0 0 0 0 0
-+– n 82 (66, 99) 29 (13, 73) 30 (15, 67) 45 (16, 78) 26 (9, 64)
-+– n_unique 82 (66, 99) 29 (13, 73) 30 (15, 67) 45 (16, 78) 26 (9, 64)
-+– post_p NA (NA, NA) 0.42 (0.09, 0.83) 0.37 (0.09, 0.82) 0.63 (0.15, 0.94) 0.65 (0.2, 0.93)
-+– rate 0.023 (0.019, 0.028) 0.026 (0.019, 0.038) 0.027 (0.02, 0.036) 0.021 (0.016, 0.032) 0.022 (0.015, 0.033)
-+-+ graduation 0 6 8 55 463
-+-+ futility 0 225 236 73 0
-+-+ max_n 0 0 0 0 0
-+-+ n 56 (43, 68) 18 (8, 46) 18 (8, 45) 27 (9, 54) 21 (9, 44)
-+-+ n_unique 56 (43, 68) 18 (8, 46) 18 (8, 45) 27 (9, 54) 21 (9, 44)
-+-+ post_p NA (NA, NA) 0.34 (0.08, 0.73) 0.35 (0.07, 0.78) 0.54 (0.17, 0.89) 0.98 (0.86, 1)
-+-+ rate 0.023 (0.018, 0.03) 0.026 (0.019, 0.041) 0.027 (0.018, 0.04) 0.021 (0.014, 0.033) 0.009 (0.005, 0.015)
-++- graduation 0 6 8 62 288
-++- futility 0 200 221 63 0
-++- max_n 0 0 0 0 0
-++- n 50 (38, 61) 19 (8, 42) 19 (9, 45) 26 (9, 48) 14 (5, 32)
-++- n_unique 50 (38, 61) 19 (8, 42) 19 (9, 45) 26 (9, 48) 14 (5, 32)
-++- post_p NA (NA, NA) 0.41 (0.1, 0.8) 0.43 (0.1, 0.83) 0.6 (0.18, 0.91) 0.56 (0.17, 0.88)
-++- rate 0.022 (0.017, 0.029) 0.026 (0.017, 0.042) 0.026 (0.018, 0.04) 0.022 (0.014, 0.033) 0.022 (0.014, 0.037)
-+++ graduation 0 6 9 67 467
-+++ futility 0 259 269 93 0
-+++ max_n 0 0 0 0 0
-+++ n 38 (29, 48) 13 (6, 31) 13 (6, 33) 21 (7, 38) 14 (6, 28)
-+++ n_unique 38 (29, 48) 13 (6, 31) 13 (6, 33) 21 (7, 38) 14 (6, 28)
-+++ post_p NA (NA, NA) 0.34 (0.07, 0.71) 0.38 (0.1, 0.75) 0.56 (0.17, 0.87) 0.95 (0.71, 1)
-+++ rate 0.022 (0.016, 0.031) 0.027 (0.017, 0.042) 0.026 (0.017, 0.042) 0.02 (0.013, 0.035) 0.01 (0.004, 0.017)
+— graduation 0 10 18 53 160
+— futility 0 31 32 11 0
+— max_n 0 0 0 0 0
+— n 40 (31, 51) 18 (8, 35) 18 (7, 33) 22 (10, 40) 17 (4, 34)
+— n_unique 40 (31, 51) 18 (8, 35) 18 (7, 33) 22 (10, 40) 17 (4, 34)
+— post_p NA (NA, NA) 0.44 (0.13, 0.82) 0.4 (0.11, 0.82) 0.56 (0.17, 0.93) 0.57 (0.19, 0.9)
+— rate 0.023 (0.017, 0.031) 0.025 (0.016, 0.041) 0.026 (0.017, 0.044) 0.022 (0.015, 0.035) 0.022 (0.013, 0.037)
+–+ graduation 0 10 20 59 451
+–+ futility 0 160 135 53 0
+–+ max_n 0 0 0 0 0
+–+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+–+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+–+ post_p NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
+–+ rate 0.03 (0.006, 0.045) 0 (0, 0) 0.085 (0.085, 0.085) 0 (0, 0) 0.015 (0.003, 0.026)
+-+- graduation 0 10 19 66 234
+-+- futility 0 116 110 41 0
+-+- max_n 0 0 0 0 0
+-+- n 29 (22, 37) 12 (6, 24) 12 (5, 26) 17 (7, 30) 10 (3, 23)
+-+- n_unique 29 (22, 37) 12 (6, 24) 12 (5, 26) 17 (7, 30) 10 (3, 23)
+-+- post_p NA (NA, NA) 0.41 (0.11, 0.77) 0.45 (0.13, 0.82) 0.58 (0.19, 0.9) 0.56 (0.19, 0.88)
+-+- rate 0.023 (0.016, 0.033) 0.027 (0.016, 0.047) 0.025 (0.015, 0.044) 0.022 (0.014, 0.037) 0.022 (0.012, 0.042)
+-++ graduation 0 10 21 72 459
+-++ futility 0 204 184 77 0
+-++ max_n 0 0 0 0 0
+-++ n 6 (3, 10) 4 (1, 7) 4 (1, 7) 4 (1, 8) 2 (0, 5)
+-++ n_unique 6 (3, 10) 4 (1, 7) 4 (1, 7) 4 (1, 8) 2 (0, 5)
+-++ post_p NA (NA, NA) 0.46 (0.3, 0.66) 0.48 (0.3, 0.65) 0.47 (0.29, 0.67) 0.6 (0.46, 0.77)
+-++ rate 0.023 (0.006, 0.049) 0.025 (0.006, 0.071) 0.024 (0, 0.071) 0.022 (0.006, 0.061) 0.007 (0, 0.024)
++– graduation 0 13 20 75 273
++– futility 0 155 178 46 0
++– max_n 0 0 0 0 0
++– n 1 (0, 3) 1 (0, 2) 0 (0, 2) 1 (0, 2) 0 (0, 2)
++– n_unique 1 (0, 3) 1 (0, 2) 0 (0, 2) 1 (0, 2) 0 (0, 2)
++– post_p NA (NA, NA) 0.5 (0.43, 0.56) 0.5 (0.44, 0.57) 0.49 (0.41, 0.57) 0.5 (0.43, 0.57)
++– rate 0.021 (0, 0.101) 0.022 (0, 0.113) 0.024 (0, 0.112) 0.023 (0, 0.111) 0.017 (0, 0.096)
++-+ graduation 0 13 21 79 465
++-+ futility 0 231 236 79 0
++-+ max_n 0 0 0 0 0
++-+ n 8 (5, 13) 5 (2, 9) 4 (1, 9) 5 (2, 10) 3 (1, 7)
++-+ n_unique 8 (5, 13) 5 (2, 9) 4 (1, 9) 5 (2, 10) 3 (1, 7)
++-+ post_p NA (NA, NA) 0.44 (0.23, 0.67) 0.45 (0.26, 0.69) 0.48 (0.26, 0.72) 0.62 (0.45, 0.84)
++-+ rate 0.023 (0.01, 0.043) 0.026 (0.008, 0.066) 0.025 (0.008, 0.062) 0.022 (0.009, 0.054) 0.009 (0, 0.026)
+++- graduation 0 13 21 87 310
+++- futility 0 207 222 71 0
+++- max_n 0 0 0 0 0
+++- n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++- n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++- post_p NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.47 (0.47, 0.48) NA (NA, NA)
+++- rate 0.028 (0.006, 0.035) 0 (0, 0.023) NA (NA, NA) 0.087 (0, 0.157) 0.027 (0.023, 0.031)
++++ graduation 0 13 22 91 469
++++ futility 0 265 268 99 0
++++ max_n 0 0 0 0 0
++++ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++++ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++++ post_p NA (NA, NA) NA (NA, NA) 0.45 (0.45, 0.45) 0.44 (0.44, 0.44) 0.52 (0.52, 0.52)
++++ rate 0 (0, 0.323) 0.041 (0, 0.112) 0.02 (0, 0.069) 0 (0, 0.155) 0 (0, 0.113)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var TC1 TC2 TC3 TC4
all count 1 4 25 129
all time_stop 9 (9, 9) 14 (11, 19) 15 (11, 33) 20 (12, 50)
all n_trt 60 (60, 60) 83 (70, 115) 70 (55, 210) 116 (57, 270)
all n_control 81 (81, 81) 124 (88, 164) 128 (93, 296) 168 (94, 496)
all post_p 0.89 (0.89, 0.89) 0.98 (0.98, 0.99) 0.93 (0.86, 1) 0.99 (0.9, 1)
all order 1 (1, 1) 1 (1, 1) 1 (1, 2) 1 (1, 2.2)
HRD+ count 9 14 28 37
HRD+ time_stop 51 (37, 52) 50 (45, 56) 50 (39, 56) 51 (45, 57)
HRD+ n_trt 52 (50, 55) 52 (50, 56) 54 (50, 65) 53 (50, 64)
HRD+ n_control 66 (50, 76) 66 (51, 77) 65 (50, 85) 68 (51, 88)
HRD+ post_p 0.92 (0.89, 0.99) 0.96 (0.88, 0.99) 0.96 (0.87, 0.99) 0.97 (0.88, 0.99)
HRD+ order 2 (1.8, 3) 2 (1.3, 3.7) 2 (1, 3.3) 2 (1, 3)
TP53+ count 5 4 26 147
TP53+ time_stop 30 (19, 34) 28 (22, 36) 38 (24, 54) 36 (26, 55)
TP53+ n_trt 85 (52, 98) 60 (51, 81) 95 (56, 154) 80 (55, 120)
TP53+ n_control 108 (57, 123) 86 (77, 134) 138 (77, 198) 121 (76, 196)
TP53+ post_p 0.97 (0.92, 0.98) 0.95 (0.92, 0.98) 0.98 (0.92, 1) 1 (0.96, 1)
TP53+ order 2 (1, 2) 1.5 (1, 2.7) 2 (1, 3.5) 2 (1, 3)
TEfus+ count 1 14 109
TEfus+ time_stop 25 (25, 25) 52 (33, 58) 36 (24, 55)
TEfus+ n_trt 50 (50, 50) 102 (65, 167) 74 (51, 103)
TEfus+ n_control 64 (64, 64) 164 (96, 205) 99 (62, 177)
TEfus+ post_p 0.97 (0.97, 0.97) 0.98 (0.96, 1) 1 (0.96, 1)
TEfus+ order 1 (1, 1) 2 (2, 4) 2 (1, 3)
PI3K+ count 1 2 9 377
PI3K+ time_stop 31 (31, 31) 28 (27, 30) 34 (25, 58) 36 (26, 50)
PI3K+ n_trt 53 (53, 53) 66 (55, 77) 61 (53, 121) 92 (60, 141)
PI3K+ n_control 88 (88, 88) 94 (82, 107) 106 (74, 208) 109 (72, 168)
PI3K+ post_p 0.96 (0.96, 0.96) 0.99 (0.99, 1) 0.98 (0.92, 1) 1 (0.99, 1)
PI3K+ order 1 (1, 1) 2.5 (2.1, 2.9) 1 (1, 4) 1 (1, 3)
Futility:
signature var TC1 TC2 TC3
all count 19 24 2
all time_stop 36 (21, 52) 34 (14, 57) 24 (17, 30)
all n_trt 135 (101, 193) 134 (69, 181) 107 (73, 141)
all n_control 338 (172, 524) 324 (116, 584) 208 (143, 273)
all post_p 0.04 (0, 0.09) 0.02 (0, 0.15) 0.02 (0.01, 0.04)
all order 2 (1, 4) 2 (1, 5) 1 (1, 1)
HRD+ count 12 8 9
HRD+ time_stop 54 (48, 58) 54 (50, 58) 51 (44, 58)
HRD+ n_trt 57 (51, 62) 52 (50, 66) 62 (51, 64)
HRD+ n_control 72 (63, 86) 83 (67, 99) 78 (53, 99)
HRD+ post_p 0.23 (0.05, 0.27) 0.05 (0.02, 0.16) 0.26 (0.18, 0.3)
HRD+ order 2 (1.1, 4.8) 2.5 (1, 4.3) 2 (1, 2.2)
TP53+ count 139 166 37
TP53+ time_stop 40 (28, 55) 33 (22, 51) 41 (28, 52)
TP53+ n_trt 68 (50, 102) 62 (50, 96) 77 (55, 132)
TP53+ n_control 142 (90, 213) 113 (60, 198) 139 (88, 202)
TP53+ post_p 0.12 (0.03, 0.25) 0.13 (0.03, 0.25) 0.14 (0.04, 0.27)
TP53+ order 1 (1, 3) 1 (1, 2.5) 2 (1, 4)
TEfus+ count 96 90 31
TEfus+ time_stop 45 (32, 56) 40 (28, 59) 42 (33, 55)
TEfus+ n_trt 62 (50, 90) 58 (51, 95) 70 (53, 101)
TEfus+ n_control 143 (91, 185) 120 (76, 188) 125 (81, 189)
TEfus+ post_p 0.09 (0.02, 0.22) 0.1 (0.03, 0.26) 0.14 (0.05, 0.24)
TEfus+ order 2 (1, 4.5) 2 (1, 4) 2 (1, 4)
PI3K+ count 144 119 45
PI3K+ time_stop 42 (32, 54) 42 (28, 56) 40 (30, 54)
PI3K+ n_trt 62 (50, 92) 62 (51, 93) 64 (52, 101)
PI3K+ n_control 142 (86, 191) 138 (80, 203) 129 (90, 212)
PI3K+ post_p 0.09 (0.02, 0.23) 0.11 (0.02, 0.26) 0.12 (0.03, 0.22)
PI3K+ order 2 (1, 4) 2 (1, 4) 2 (1, 4)


By subgroup combinations

Graduation:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all TC1 count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
all TC1 time 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9)
all TC1 n 30 (30, 30) 4 (4, 4) 2 (2, 2) 3 (3, 3) 6 (6, 6) 3 (3, 3) 3 (3, 3) 4 (4, 4) 2 (2, 2) 0 (0, 0) 2 (2, 2) 1 (1, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 post_p 0.68 (0.68, 0.68) 0.52 (0.52, 0.52) NA (NA, NA) 0.51 (0.51, 0.51) 0.52 (0.52, 0.52) 0.52 (0.52, 0.52) 0.52 (0.52, 0.52) 0.51 (0.51, 0.51) 0.52 (0.52, 0.52) NA (NA, NA) 0.53 (0.53, 0.53) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC1 r_prob 0.37 (0.37, 0.37) 0.27 (0.27, 0.27) 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 rate 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0.332 (0.332, 0.332) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC2 count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
all TC2 time 14 (11, 19) 14 (11, 19) 14 (11, 19) 14 (11, 19) 14 (11, 19) 14 (11, 19) 14 (11, 19) 14 (11, 19) 14 (11, 19) 14 (11, 19) 14 (11, 19) 14 (11, 19) 14 (11, 19) 14 (11, 19) 14 (11, 19) 14 (11, 19)
all TC2 n 30 (22, 36) 5 (3, 6) 2 (0, 4) 10 (6, 13) 14 (10, 22) 8 (6, 11) 8 (6, 10) 4 (4, 5) 2 (1, 8) 0 (0, 0) 2 (2, 4) 0 (0, 1) 0 (0, 1) 1 (0, 1) 0 (0, 0) 0 (0, 0)
all TC2 post_p 0.77 (0.66, 0.8) 0.53 (0.52, 0.54) 0.5 (0.5, 0.5) 0.53 (0.52, 0.68) 0.59 (0.57, 0.61) 0.57 (0.52, 0.61) 0.53 (0.52, 0.57) 0.56 (0.52, 0.61) 0.53 (0.51, 0.54) NA (NA, NA) 0.53 (0.51, 0.55) NA (NA, NA) NA (NA, NA) 0.54 (0.54, 0.54) NA (NA, NA) NA (NA, NA)
all TC2 r_prob 0.25 (0.25, 0.25) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 rate 0.002 (0, 0.011) 0 (0, 0) 0 (0, 0.017) 0.006 (0, 0.012) 0.002 (0, 0.006) 0.004 (0, 0.021) 0.014 (0.004, 0.022) 0 (0, 0) 0 (0, 0.012) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA)
all TC3 count 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25
all TC3 time 15 (11, 33) 15 (11, 33) 15 (11, 33) 15 (11, 33) 15 (11, 33) 15 (11, 33) 15 (11, 33) 15 (11, 33) 15 (11, 33) 15 (11, 33) 15 (11, 33) 15 (11, 33) 15 (11, 33) 15 (11, 33) 15 (11, 33) 15 (11, 33)
all TC3 n 17 (11, 50) 4 (0, 14) 1 (0, 6) 7 (1, 24) 9 (4, 36) 7 (3, 16) 6 (3, 17) 4 (2, 15) 10 (5, 18) 0 (0, 0) 8 (3, 14) 1 (0, 2) 0 (0, 1) 1 (0, 5) 0 (0, 0) 0 (0, 0)
all TC3 post_p 0.58 (0.54, 0.83) 0.54 (0.51, 0.63) 0.54 (0.51, 0.73) 0.56 (0.51, 0.65) 0.57 (0.52, 0.8) 0.53 (0.52, 0.71) 0.54 (0.52, 0.63) 0.53 (0.52, 0.6) 0.55 (0.51, 0.67) NA (NA, NA) 0.55 (0.51, 0.67) 0.53 (0.5, 0.56) NA (NA, NA) 0.52 (0.5, 0.55) NA (NA, NA) NA (NA, NA)
all TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
all TC3 rate 0.005 (0, 0.019) 0 (0, 0.019) 0 (0, 0.006) 0 (0, 0.012) 0 (0, 0.014) 0 (0, 0.014) 0 (0, 0.02) 0 (0, 0.013) 0 (0, 0.016) NA (NA, NA) 0 (0, 0.02) 0 (0, 0) 0 (0, 0) 0 (0, 0.012) NA (NA, NA) 0.075 (0.073, 0.078)
all TC4 count 129 129 129 129 129 129 129 129 129 129 129 129 129 129 129 129
all TC4 time 20 (12, 50) 20 (12, 50) 20 (12, 50) 20 (12, 50) 20 (12, 50) 20 (12, 50) 20 (12, 50) 20 (12, 50) 20 (12, 50) 20 (12, 50) 20 (12, 50) 20 (12, 50) 20 (12, 50) 20 (12, 50) 20 (12, 50) 20 (12, 50)
all TC4 n 30 (12, 93) 10 (5, 23) 2 (0, 5) 14 (7, 34) 13 (5, 32) 13 (7, 27) 8 (3, 18) 9 (3, 18) 6 (2, 21) 0 (0, 0) 4 (1, 13) 1 (0, 4) 0 (0, 1) 2 (0, 5) 0 (0, 0) 0 (0, 0)
all TC4 post_p 0.68 (0.52, 0.9) 0.6 (0.52, 0.98) 0.54 (0.5, 0.66) 0.6 (0.53, 0.99) 0.57 (0.51, 0.81) 0.61 (0.52, 0.95) 0.56 (0.51, 0.76) 0.58 (0.52, 0.92) 0.55 (0.51, 0.82) NA (NA, NA) 0.54 (0.51, 0.73) 0.53 (0.51, 0.6) 0.53 (0.52, 0.56) 0.54 (0.51, 0.63) NA (NA, NA) NA (NA, NA)
all TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
all TC4 rate 0.013 (0, 0.022) 0 (0, 0.013) 0 (0, 0.021) 0.007 (0, 0.013) 0.013 (0, 0.022) 0.005 (0, 0.015) 0 (0, 0.022) 0 (0, 0.015) 0 (0, 0.023) 0.029 (0.029, 0.029) 0 (0, 0.021) 0 (0, 0.014) 0 (0, 0) 0 (0, 0.014) NA (NA, NA) 0 (0, 0)
HRD+ TC1 count 9 9 9 9 9 9 9 9
HRD+ TC1 time 51 (37, 52) 51 (37, 52) 51 (37, 52) 51 (37, 52) 51 (37, 52) 51 (37, 52) 51 (37, 52) 51 (37, 52)
HRD+ TC1 n 27 (18, 32) 0 (0, 0) 17 (11, 22) 4 (2, 7) 0 (0, 1) 4 (2, 10) 0 (0, 0) 0 (0, 0)
HRD+ TC1 post_p 0.83 (0.72, 0.93) NA (NA, NA) 0.73 (0.67, 0.86) 0.53 (0.51, 0.58) 0.52 (0.51, 0.53) 0.61 (0.53, 0.9) NA (NA, NA) NA (NA, NA)
HRD+ TC1 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 rate 0.018 (0.015, 0.02) NA (NA, NA) 0.015 (0.011, 0.029) 0 (0, 0.034) 0 (0, 0.042) 0 (0, 0.022) NA (NA, NA) NA (NA, NA)
HRD+ TC2 count 14 14 14 14 14 14 14 14
HRD+ TC2 time 50 (45, 56) 50 (45, 56) 50 (45, 56) 50 (45, 56) 50 (45, 56) 50 (45, 56) 50 (45, 56) 50 (45, 56)
HRD+ TC2 n 28 (20, 32) 0 (0, 0) 17 (13, 23) 4 (2, 7) 1 (0, 2) 5 (2, 8) 0 (0, 0) 0 (0, 0)
HRD+ TC2 post_p 0.81 (0.73, 0.91) NA (NA, NA) 0.8 (0.71, 0.91) 0.56 (0.52, 0.66) 0.53 (0.52, 0.57) 0.56 (0.51, 0.68) NA (NA, NA) NA (NA, NA)
HRD+ TC2 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC2 rate 0.018 (0.013, 0.021) NA (NA, NA) 0.015 (0.009, 0.02) 0.01 (0, 0.027) 0 (0, 0.066) 0.012 (0, 0.026) NA (NA, NA) NA (NA, NA)
HRD+ TC3 count 28 28 28 28 28 28 28 28
HRD+ TC3 time 50 (39, 56) 50 (39, 56) 50 (39, 56) 50 (39, 56) 50 (39, 56) 50 (39, 56) 50 (39, 56) 50 (39, 56)
HRD+ TC3 n 26 (19, 38) 0 (0, 0) 22 (13, 27) 4 (2, 5) 0 (0, 1) 5 (3, 8) 0 (0, 0) 0 (0, 0)
HRD+ TC3 post_p 0.84 (0.72, 0.96) NA (NA, NA) 0.81 (0.71, 0.88) 0.53 (0.51, 0.63) 0.51 (0.51, 0.56) 0.55 (0.51, 0.65) 0.52 (0.52, 0.52) NA (NA, NA)
HRD+ TC3 r_prob 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
HRD+ TC3 rate 0.015 (0.009, 0.022) NA (NA, NA) 0.017 (0.012, 0.023) 0.005 (0, 0.024) 0 (0, 0.063) 0.015 (0, 0.021) 0.166 (0.118, 0.215) NA (NA, NA)
HRD+ TC4 count 37 37 37 37 37 37 37 37
HRD+ TC4 time 51 (45, 57) 51 (45, 57) 51 (45, 57) 51 (45, 57) 51 (45, 57) 51 (45, 57) 51 (45, 57) 51 (45, 57)
HRD+ TC4 n 28 (24, 37) 0 (0, 0) 17 (10, 26) 4 (1, 7) 0 (0, 2) 4 (1, 8) 0 (0, 0) 0 (0, 0)
HRD+ TC4 post_p 0.79 (0.71, 0.95) NA (NA, NA) 0.8 (0.57, 0.96) 0.57 (0.52, 0.69) 0.53 (0.5, 0.56) 0.6 (0.54, 0.82) NA (NA, NA) NA (NA, NA)
HRD+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
HRD+ TC4 rate 0.015 (0.01, 0.019) NA (NA, NA) 0.015 (0.007, 0.022) 0.007 (0, 0.018) 0 (0, 0.083) 0 (0, 0.011) 0.016 (0.003, 0.029) 0 (0, 0)
TP53+ TC1 count 5 5 5 5 5 5 5 5
TP53+ TC1 time 30 (19, 34) 30 (19, 34) 30 (19, 34) 30 (19, 34) 30 (19, 34) 30 (19, 34) 30 (19, 34) 30 (19, 34)
TP53+ TC1 n 19 (17, 32) 10 (9, 27) 22 (13, 25) 14 (10, 20) 0 (0, 1) 3 (1, 7) 0 (0, 0) 0 (0, 0)
TP53+ TC1 post_p 0.77 (0.75, 0.87) 0.6 (0.59, 0.81) 0.77 (0.73, 0.82) 0.71 (0.52, 0.82) NA (NA, NA) 0.53 (0.51, 0.53) NA (NA, NA) NA (NA, NA)
TP53+ TC1 r_prob 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 rate 0.01 (0.006, 0.014) 0.008 (0, 0.014) 0.009 (0.003, 0.016) 0.007 (0, 0.016) 0 (0, 0) 0.008 (0, 0.027) NA (NA, NA) NA (NA, NA)
TP53+ TC2 count 4 4 4 4 4 4 4 4
TP53+ TC2 time 28 (22, 36) 28 (22, 36) 28 (22, 36) 28 (22, 36) 28 (22, 36) 28 (22, 36) 28 (22, 36) 28 (22, 36)
TP53+ TC2 n 25 (25, 38) 16 (8, 23) 9 (9, 10) 9 (5, 10) 0 (0, 1) 1 (0, 2) 0 (0, 0) 0 (0, 0)
TP53+ TC2 post_p 0.8 (0.75, 0.87) 0.82 (0.59, 0.87) 0.52 (0.5, 0.59) 0.58 (0.55, 0.64) 0.54 (0.54, 0.54) 0.53 (0.51, 0.53) NA (NA, NA) NA (NA, NA)
TP53+ TC2 r_prob 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 rate 0.011 (0.006, 0.013) 0.011 (0.005, 0.016) 0.016 (0.004, 0.021) 0.009 (0.007, 0.012) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA)
TP53+ TC3 count 26 26 26 26 26 26 26 26
TP53+ TC3 time 38 (24, 54) 38 (24, 54) 38 (24, 54) 38 (24, 54) 38 (24, 54) 38 (24, 54) 38 (24, 54) 38 (24, 54)
TP53+ TC3 n 27 (20, 57) 20 (12, 38) 22 (10, 32) 14 (8, 24) 0 (0, 1) 4 (0, 7) 0 (0, 0) 0 (0, 0)
TP53+ TC3 post_p 0.84 (0.72, 0.95) 0.75 (0.71, 0.9) 0.77 (0.59, 0.86) 0.73 (0.54, 0.85) 0.53 (0.51, 0.6) 0.55 (0.51, 0.6) NA (NA, NA) NA (NA, NA)
TP53+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
TP53+ TC3 rate 0.014 (0.002, 0.018) 0.012 (0.002, 0.017) 0.013 (0.004, 0.018) 0.013 (0, 0.017) 0.015 (0, 0.19) 0.016 (0, 0.032) NA (NA, NA) NA (NA, NA)
TP53+ TC4 count 147 147 147 147 147 147 147 147
TP53+ TC4 time 36 (26, 55) 36 (26, 55) 36 (26, 55) 36 (26, 55) 36 (26, 55) 36 (26, 55) 36 (26, 55) 36 (26, 55)
TP53+ TC4 n 25 (13, 45) 22 (13, 34) 15 (7, 28) 14 (8, 23) 0 (0, 1) 3 (1, 6) 0 (0, 0) 0 (0, 0)
TP53+ TC4 post_p 0.76 (0.7, 0.91) 0.9 (0.72, 0.99) 0.73 (0.54, 0.87) 0.78 (0.56, 0.98) 0.53 (0.51, 0.56) 0.56 (0.51, 0.65) NA (NA, NA) 0.54 (0.54, 0.54)
TP53+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
TP53+ TC4 rate 0.015 (0.006, 0.02) 0.008 (0.002, 0.013) 0.014 (0, 0.021) 0.007 (0, 0.013) 0 (0, 0.057) 0 (0, 0.019) NA (NA, NA) 0 (0, 0.096)
TEfus+ TC2 count 1 1 1 1 1 1 1 1
TEfus+ TC2 time 25 (25, 25) 25 (25, 25) 25 (25, 25) 25 (25, 25) 25 (25, 25) 25 (25, 25) 25 (25, 25) 25 (25, 25)
TEfus+ TC2 n 3 (3, 3) 16 (16, 16) 18 (18, 18) 10 (10, 10) 2 (2, 2) 1 (1, 1) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 post_p 0.53 (0.53, 0.53) 0.71 (0.71, 0.71) 0.87 (0.87, 0.87) 0.52 (0.52, 0.52) 0.56 (0.56, 0.56) 0.55 (0.55, 0.55) NA (NA, NA) NA (NA, NA)
TEfus+ TC2 r_prob 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 rate 0 (0, 0) 0.006 (0.006, 0.006) 0.005 (0.005, 0.005) 0.011 (0.011, 0.011) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA)
TEfus+ TC3 count 14 14 14 14 14 14 14 14
TEfus+ TC3 time 52 (33, 58) 52 (33, 58) 52 (33, 58) 52 (33, 58) 52 (33, 58) 52 (33, 58) 52 (33, 58) 52 (33, 58)
TEfus+ TC3 n 5 (2, 10) 36 (18, 58) 24 (10, 38) 22 (7, 41) 16 (9, 25) 4 (2, 6) 0 (0, 0) 0 (0, 0)
TEfus+ TC3 post_p 0.6 (0.52, 0.81) 0.86 (0.74, 0.92) 0.8 (0.71, 0.95) 0.74 (0.6, 0.86) 0.74 (0.6, 0.94) 0.55 (0.51, 0.6) NA (NA, NA) NA (NA, NA)
TEfus+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
TEfus+ TC3 rate 0.016 (0, 0.025) 0.014 (0.01, 0.02) 0.014 (0.009, 0.02) 0.013 (0.01, 0.019) 0.015 (0.009, 0.023) 0.011 (0, 0.029) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 count 109 109 109 109 109 109 109 109
TEfus+ TC4 time 36 (24, 55) 36 (24, 55) 36 (24, 55) 36 (24, 55) 36 (24, 55) 36 (24, 55) 36 (24, 55) 36 (24, 55)
TEfus+ TC4 n 4 (2, 8) 28 (19, 41) 14 (7, 27) 14 (8, 22) 9 (4, 17) 3 (0, 5) 0 (0, 0) 0 (0, 0)
TEfus+ TC4 post_p 0.56 (0.51, 0.7) 0.92 (0.71, 1) 0.72 (0.53, 0.89) 0.8 (0.56, 0.98) 0.63 (0.51, 0.86) 0.55 (0.51, 0.63) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
TEfus+ TC4 rate 0.009 (0, 0.025) 0.007 (0.002, 0.012) 0.012 (0, 0.022) 0.007 (0, 0.012) 0.011 (0, 0.024) 0 (0, 0.018) NA (NA, NA) 0 (0, 0)
PI3K+ TC1 count 1 1 1 1 1 1 1 1
PI3K+ TC1 time 31 (31, 31) 31 (31, 31) 31 (31, 31) 31 (31, 31) 31 (31, 31) 31 (31, 31) 31 (31, 31) 31 (31, 31)
PI3K+ TC1 n 6 (6, 6) 17 (17, 17) 16 (16, 16) 8 (8, 8) 0 (0, 0) 3 (3, 3) 3 (3, 3) 0 (0, 0)
PI3K+ TC1 post_p 0.51 (0.51, 0.51) 0.79 (0.79, 0.79) 0.78 (0.78, 0.78) 0.68 (0.68, 0.68) NA (NA, NA) 0.55 (0.55, 0.55) 0.54 (0.54, 0.54) NA (NA, NA)
PI3K+ TC1 r_prob 0.27 (0.27, 0.27) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 rate 0.023 (0.023, 0.023) 0.006 (0.006, 0.006) 0.019 (0.019, 0.019) 0.007 (0.007, 0.007) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA)
PI3K+ TC2 count 2 2 2 2 2 2 2 2
PI3K+ TC2 time 28 (27, 30) 28 (27, 30) 28 (27, 30) 28 (27, 30) 28 (27, 30) 28 (27, 30) 28 (27, 30) 28 (27, 30)
PI3K+ TC2 n 18 (16, 19) 16 (11, 22) 18 (9, 26) 9 (8, 10) 0 (0, 0) 4 (4, 5) 1 (1, 1) 0 (0, 0)
PI3K+ TC2 post_p 0.77 (0.73, 0.82) 0.63 (0.57, 0.69) 0.74 (0.62, 0.86) 0.68 (0.62, 0.74) NA (NA, NA) 0.58 (0.57, 0.59) 0.55 (0.55, 0.55) NA (NA, NA)
PI3K+ TC2 r_prob 0.07 (0.07, 0.07) 0.27 (0.27, 0.27) 0.27 (0.27, 0.27) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 rate 0.006 (0.001, 0.011) 0.011 (0.008, 0.014) 0.007 (0.007, 0.008) 0.012 (0.011, 0.013) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA)
PI3K+ TC3 count 9 9 9 9 9 9 9 9
PI3K+ TC3 time 34 (25, 58) 34 (25, 58) 34 (25, 58) 34 (25, 58) 34 (25, 58) 34 (25, 58) 34 (25, 58) 34 (25, 58)
PI3K+ TC3 n 20 (10, 30) 19 (9, 44) 18 (12, 26) 9 (7, 25) 0 (0, 0) 2 (1, 3) 3 (2, 6) 0 (0, 0)
PI3K+ TC3 post_p 0.73 (0.6, 0.81) 0.73 (0.59, 0.86) 0.8 (0.67, 0.92) 0.67 (0.53, 0.79) NA (NA, NA) 0.56 (0.52, 0.62) 0.55 (0.51, 0.64) NA (NA, NA)
PI3K+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC3 rate 0.013 (0.008, 0.022) 0.01 (0.003, 0.014) 0.006 (0, 0.018) 0.013 (0, 0.021) NA (NA, NA) 0 (0, 0.015) 0.005 (0, 0.014) 0.078 (0.078, 0.078)
PI3K+ TC4 count 377 377 377 377 377 377 377 377
PI3K+ TC4 time 36 (26, 50) 36 (26, 50) 36 (26, 50) 36 (26, 50) 36 (26, 50) 36 (26, 50) 36 (26, 50) 36 (26, 50)
PI3K+ TC4 n 18 (9, 34) 28 (17, 48) 22 (13, 40) 15 (8, 27) 0 (0, 0) 3 (1, 5) 3 (1, 7) 0 (0, 0)
PI3K+ TC4 post_p 0.82 (0.65, 0.99) 0.9 (0.71, 1) 0.86 (0.71, 0.99) 0.76 (0.56, 0.96) NA (NA, NA) 0.54 (0.51, 0.63) 0.55 (0.51, 0.69) 0.54 (0.54, 0.54)
PI3K+ TC4 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.31 (0.31, 0.31) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC4 rate 0.007 (0, 0.014) 0.008 (0.002, 0.014) 0.008 (0, 0.014) 0.008 (0, 0.014) 0.029 (0.029, 0.029) 0 (0, 0.021) 0 (0, 0.019) 0 (0, 0.029)
Futility:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all TC1 count 19 19 19 19 19 19 19 19 19 19 19 19 19 19 19 19
all TC1 time 36 (21, 52) 36 (21, 52) 36 (21, 52) 36 (21, 52) 36 (21, 52) 36 (21, 52) 36 (21, 52) 36 (21, 52) 36 (21, 52) 36 (21, 52) 36 (21, 52) 36 (21, 52) 36 (21, 52) 36 (21, 52) 36 (21, 52) 36 (21, 52)
all TC1 n 36 (24, 60) 14 (7, 21) 4 (2, 8) 12 (4, 20) 16 (9, 24) 10 (4, 17) 13 (5, 20) 7 (3, 13) 8 (3, 13) 0 (0, 0) 8 (4, 13) 1 (0, 3) 0 (0, 1) 3 (1, 4) 0 (0, 0) 0 (0, 0)
all TC1 post_p 0.28 (0.06, 0.45) 0.38 (0.11, 0.46) 0.41 (0.21, 0.49) 0.33 (0.14, 0.47) 0.34 (0.09, 0.45) 0.32 (0.09, 0.47) 0.38 (0.12, 0.49) 0.37 (0.24, 0.46) 0.39 (0.17, 0.49) NA (NA, NA) 0.4 (0.23, 0.5) 0.46 (0.37, 0.47) 0.49 (0.49, 0.5) 0.42 (0.37, 0.48) NA (NA, NA) NA (NA, NA)
all TC1 r_prob 0.37 (0.37, 0.37) 0.27 (0.27, 0.27) 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 rate 0.027 (0.02, 0.037) 0.027 (0.019, 0.036) 0.036 (0.016, 0.07) 0.031 (0.02, 0.048) 0.028 (0.023, 0.039) 0.032 (0.016, 0.063) 0.028 (0.019, 0.048) 0.03 (0.021, 0.051) 0.031 (0.012, 0.069) NA (NA, NA) 0.025 (0.013, 0.051) 0.039 (0.011, 0.093) 0 (0, 0.07) 0.034 (0, 0.098) NA (NA, NA) 0 (0, 0)
all TC2 count 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24
all TC2 time 34 (14, 57) 34 (14, 57) 34 (14, 57) 34 (14, 57) 34 (14, 57) 34 (14, 57) 34 (14, 57) 34 (14, 57) 34 (14, 57) 34 (14, 57) 34 (14, 57) 34 (14, 57) 34 (14, 57) 34 (14, 57) 34 (14, 57) 34 (14, 57)
all TC2 n 28 (20, 61) 9 (2, 18) 5 (0, 9) 14 (7, 22) 17 (10, 34) 10 (7, 17) 12 (7, 21) 6 (4, 12) 8 (2, 14) 0 (0, 0) 6 (2, 10) 2 (0, 5) 0 (0, 1) 1 (0, 6) 0 (0, 0) 0 (0, 0)
all TC2 post_p 0.27 (0.07, 0.42) 0.39 (0.23, 0.47) 0.4 (0.29, 0.49) 0.26 (0.08, 0.43) 0.31 (0.17, 0.45) 0.35 (0.12, 0.43) 0.31 (0.09, 0.49) 0.31 (0.12, 0.45) 0.31 (0.1, 0.49) NA (NA, NA) 0.42 (0.17, 0.49) 0.47 (0.4, 0.49) 0.47 (0.46, 0.48) 0.45 (0.34, 0.49) NA (NA, NA) NA (NA, NA)
all TC2 r_prob 0.25 (0.25, 0.25) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 rate 0.027 (0.022, 0.036) 0.026 (0.017, 0.047) 0.023 (0.011, 0.068) 0.027 (0.018, 0.038) 0.025 (0.019, 0.034) 0.032 (0.018, 0.054) 0.029 (0.015, 0.041) 0.033 (0.022, 0.067) 0.034 (0.005, 0.053) 0.085 (0.085, 0.085) 0.038 (0.016, 0.075) 0.018 (0, 0.058) 0.04 (0, 0.53) 0.024 (0, 0.135) NA (NA, NA) NA (NA, NA)
all TC3 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
all TC3 time 24 (17, 30) 24 (17, 30) 24 (17, 30) 24 (17, 30) 24 (17, 30) 24 (17, 30) 24 (17, 30) 24 (17, 30) 24 (17, 30) 24 (17, 30) 24 (17, 30) 24 (17, 30) 24 (17, 30) 24 (17, 30) 24 (17, 30) 24 (17, 30)
all TC3 n 28 (20, 37) 6 (4, 7) 2 (1, 2) 10 (6, 14) 14 (10, 19) 5 (4, 6) 10 (6, 14) 8 (4, 12) 12 (8, 16) 0 (0, 0) 8 (6, 9) 2 (0, 3) 0 (0, 1) 2 (2, 3) 0 (0, 0) 0 (0, 0)
all TC3 post_p 0.33 (0.31, 0.34) 0.3 (0.19, 0.4) 0.39 (0.32, 0.47) 0.34 (0.3, 0.37) 0.3 (0.25, 0.34) 0.39 (0.38, 0.39) 0.38 (0.36, 0.39) 0.46 (0.44, 0.48) 0.42 (0.36, 0.47) NA (NA, NA) 0.39 (0.31, 0.47) 0.49 (0.49, 0.49) 0.46 (0.46, 0.46) 0.42 (0.42, 0.42) NA (NA, NA) NA (NA, NA)
all TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
all TC3 rate 0.027 (0.022, 0.031) 0.05 (0.046, 0.055) 0.122 (0.024, 0.219) 0.044 (0.032, 0.056) 0.036 (0.035, 0.038) 0.059 (0.035, 0.083) 0.03 (0.019, 0.04) 0.008 (0.002, 0.015) 0.024 (0.02, 0.028) NA (NA, NA) 0.029 (0.023, 0.034) 0.026 (0.026, 0.026) 0 (0, 0) 0.017 (0.003, 0.031) NA (NA, NA) NA (NA, NA)
HRD+ TC1 count 12 12 12 12 12 12 12 12
HRD+ TC1 time 54 (48, 58) 54 (48, 58) 54 (48, 58) 54 (48, 58) 54 (48, 58) 54 (48, 58) 54 (48, 58) 54 (48, 58)
HRD+ TC1 n 31 (25, 40) 0 (0, 0) 16 (12, 22) 4 (2, 7) 0 (0, 2) 4 (2, 8) 0 (0, 0) 0 (0, 0)
HRD+ TC1 post_p 0.39 (0.26, 0.45) NA (NA, NA) 0.34 (0.17, 0.46) 0.4 (0.36, 0.44) 0.48 (0.46, 0.49) 0.38 (0.3, 0.45) NA (NA, NA) NA (NA, NA)
HRD+ TC1 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 rate 0.025 (0.022, 0.028) 0 (0, 0) 0.028 (0.022, 0.035) 0.032 (0.024, 0.12) 0.051 (0.008, 0.91) 0.027 (0.021, 0.042) NA (NA, NA) NA (NA, NA)
HRD+ TC2 count 8 8 8 8 8 8 8 8
HRD+ TC2 time 54 (50, 58) 54 (50, 58) 54 (50, 58) 54 (50, 58) 54 (50, 58) 54 (50, 58) 54 (50, 58) 54 (50, 58)
HRD+ TC2 n 24 (18, 34) 0 (0, 0) 22 (17, 30) 4 (1, 6) 0 (0, 2) 4 (2, 7) 0 (0, 0) 0 (0, 0)
HRD+ TC2 post_p 0.16 (0.05, 0.48) NA (NA, NA) 0.24 (0.08, 0.45) 0.44 (0.42, 0.49) 0.43 (0.42, 0.44) 0.42 (0.27, 0.49) NA (NA, NA) NA (NA, NA)
HRD+ TC2 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC2 rate 0.027 (0.021, 0.038) NA (NA, NA) 0.032 (0.02, 0.038) 0.028 (0.016, 0.054) 0.013 (0.003, 0.078) 0.027 (0.02, 0.046) NA (NA, NA) 0 (0, 0)
HRD+ TC3 count 9 9 9 9 9 9 9 9
HRD+ TC3 time 51 (44, 58) 51 (44, 58) 51 (44, 58) 51 (44, 58) 51 (44, 58) 51 (44, 58) 51 (44, 58) 51 (44, 58)
HRD+ TC3 n 27 (17, 34) 0 (0, 0) 22 (12, 31) 5 (2, 7) 1 (0, 3) 5 (4, 7) 0 (0, 0) 0 (0, 0)
HRD+ TC3 post_p 0.36 (0.18, 0.44) NA (NA, NA) 0.4 (0.34, 0.47) 0.42 (0.39, 0.46) 0.45 (0.42, 0.48) 0.43 (0.31, 0.45) NA (NA, NA) NA (NA, NA)
HRD+ TC3 r_prob 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
HRD+ TC3 rate 0.027 (0.022, 0.036) NA (NA, NA) 0.025 (0.016, 0.03) 0.029 (0.014, 0.035) 0.025 (0.009, 0.095) 0.025 (0.02, 0.049) NA (NA, NA) NA (NA, NA)
TP53+ TC1 count 139 139 139 139 139 139 139 139
TP53+ TC1 time 40 (28, 55) 40 (28, 55) 40 (28, 55) 40 (28, 55) 40 (28, 55) 40 (28, 55) 40 (28, 55) 40 (28, 55)
TP53+ TC1 n 22 (13, 44) 13 (8, 30) 15 (7, 28) 11 (6, 20) 0 (0, 2) 3 (1, 6) 0 (0, 0) 0 (0, 0)
TP53+ TC1 post_p 0.35 (0.12, 0.47) 0.3 (0.08, 0.48) 0.36 (0.12, 0.48) 0.34 (0.14, 0.48) 0.46 (0.43, 0.49) 0.43 (0.29, 0.49) NA (NA, NA) NA (NA, NA)
TP53+ TC1 r_prob 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 rate 0.026 (0.019, 0.039) 0.028 (0.019, 0.046) 0.027 (0.02, 0.045) 0.028 (0.02, 0.043) 0.008 (0, 0.114) 0.033 (0, 0.098) NA (NA, NA) 0 (0, 0.775)
TP53+ TC2 count 166 166 166 166 166 166 166 166
TP53+ TC2 time 33 (22, 51) 33 (22, 51) 33 (22, 51) 33 (22, 51) 33 (22, 51) 33 (22, 51) 33 (22, 51) 33 (22, 51)
TP53+ TC2 n 22 (14, 38) 13 (8, 25) 14 (8, 28) 9 (5, 18) 0 (0, 1) 2 (0, 6) 0 (0, 0) 0 (0, 0)
TP53+ TC2 post_p 0.32 (0.13, 0.47) 0.35 (0.1, 0.48) 0.35 (0.15, 0.48) 0.34 (0.17, 0.47) 0.48 (0.43, 0.5) 0.45 (0.35, 0.5) NA (NA, NA) NA (NA, NA)
TP53+ TC2 r_prob 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 rate 0.026 (0.018, 0.036) 0.026 (0.016, 0.047) 0.026 (0.019, 0.04) 0.028 (0.017, 0.053) 0.018 (0, 0.157) 0.032 (0, 0.08) NA (NA, NA) 0 (0, 0.056)
TP53+ TC3 count 37 37 37 37 37 37 37 37
TP53+ TC3 time 41 (28, 52) 41 (28, 52) 41 (28, 52) 41 (28, 52) 41 (28, 52) 41 (28, 52) 41 (28, 52) 41 (28, 52)
TP53+ TC3 n 27 (12, 52) 14 (8, 27) 18 (7, 34) 13 (7, 27) 0 (0, 1) 3 (1, 6) 0 (0, 0) 0 (0, 0)
TP53+ TC3 post_p 0.35 (0.07, 0.48) 0.37 (0.16, 0.45) 0.39 (0.19, 0.48) 0.39 (0.2, 0.47) 0.46 (0.44, 0.48) 0.47 (0.27, 0.5) NA (NA, NA) 0.43 (0.43, 0.43)
TP53+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
TP53+ TC3 rate 0.024 (0.018, 0.039) 0.024 (0.019, 0.035) 0.023 (0.016, 0.039) 0.025 (0.017, 0.04) 0 (0, 0.096) 0.028 (0.013, 0.094) NA (NA, NA) 0.027 (0.027, 0.027)
TEfus+ TC1 count 96 96 96 96 96 96 96 96
TEfus+ TC1 time 45 (32, 56) 45 (32, 56) 45 (32, 56) 45 (32, 56) 45 (32, 56) 45 (32, 56) 45 (32, 56) 45 (32, 56)
TEfus+ TC1 n 6 (2, 9) 17 (11, 32) 15 (8, 23) 11 (6, 22) 8 (5, 16) 2 (0, 5) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 post_p 0.4 (0.22, 0.49) 0.31 (0.07, 0.46) 0.34 (0.14, 0.49) 0.34 (0.13, 0.47) 0.36 (0.12, 0.48) 0.45 (0.35, 0.49) NA (NA, NA) NA (NA, NA)
TEfus+ TC1 r_prob 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 rate 0.03 (0.02, 0.062) 0.026 (0.018, 0.035) 0.026 (0.019, 0.04) 0.027 (0.02, 0.042) 0.03 (0.02, 0.052) 0.035 (0.014, 0.085) NA (NA, NA) 0.045 (0.009, 0.081)
TEfus+ TC2 count 90 90 90 90 90 90 90 90
TEfus+ TC2 time 40 (28, 59) 40 (28, 59) 40 (28, 59) 40 (28, 59) 40 (28, 59) 40 (28, 59) 40 (28, 59) 40 (28, 59)
TEfus+ TC2 n 6 (3, 10) 16 (11, 30) 16 (8, 29) 10 (6, 21) 9 (5, 18) 2 (0, 6) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 post_p 0.42 (0.3, 0.48) 0.27 (0.09, 0.48) 0.33 (0.11, 0.47) 0.34 (0.15, 0.48) 0.39 (0.16, 0.49) 0.45 (0.37, 0.49) NA (NA, NA) NA (NA, NA)
TEfus+ TC2 r_prob 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 rate 0.029 (0.016, 0.042) 0.027 (0.018, 0.039) 0.027 (0.019, 0.041) 0.027 (0.018, 0.043) 0.031 (0.02, 0.056) 0.031 (0.014, 0.104) NA (NA, NA) NA (NA, NA)
TEfus+ TC3 count 31 31 31 31 31 31 31 31
TEfus+ TC3 time 42 (33, 55) 42 (33, 55) 42 (33, 55) 42 (33, 55) 42 (33, 55) 42 (33, 55) 42 (33, 55) 42 (33, 55)
TEfus+ TC3 n 5 (2, 8) 19 (13, 42) 17 (8, 31) 11 (6, 29) 10 (5, 18) 3 (1, 6) 0 (0, 0) 0 (0, 0)
TEfus+ TC3 post_p 0.46 (0.28, 0.48) 0.36 (0.2, 0.48) 0.4 (0.23, 0.48) 0.38 (0.17, 0.49) 0.32 (0.19, 0.46) 0.46 (0.33, 0.48) 0.43 (0.43, 0.43) NA (NA, NA)
TEfus+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
TEfus+ TC3 rate 0.027 (0.018, 0.068) 0.023 (0.017, 0.029) 0.023 (0.018, 0.04) 0.027 (0.017, 0.043) 0.027 (0.018, 0.042) 0.026 (0, 0.056) 0.088 (0.088, 0.088) NA (NA, NA)
PI3K+ TC1 count 144 144 144 144 144 144 144 144
PI3K+ TC1 time 42 (32, 54) 42 (32, 54) 42 (32, 54) 42 (32, 54) 42 (32, 54) 42 (32, 54) 42 (32, 54) 42 (32, 54)
PI3K+ TC1 n 13 (7, 22) 16 (9, 34) 14 (7, 27) 11 (6, 20) 0 (0, 0) 2 (0, 5) 3 (1, 7) 0 (0, 0)
PI3K+ TC1 post_p 0.3 (0.08, 0.45) 0.28 (0.11, 0.48) 0.29 (0.09, 0.47) 0.31 (0.08, 0.48) NA (NA, NA) 0.45 (0.35, 0.5) 0.44 (0.32, 0.49) NA (NA, NA)
PI3K+ TC1 r_prob 0.27 (0.27, 0.27) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 rate 0.027 (0.019, 0.045) 0.027 (0.019, 0.038) 0.027 (0.019, 0.048) 0.029 (0.019, 0.045) NA (NA, NA) 0.033 (0.013, 0.091) 0.032 (0.016, 0.092) 0 (0, 0.079)
PI3K+ TC2 count 119 119 119 119 119 119 119 119
PI3K+ TC2 time 42 (28, 56) 42 (28, 56) 42 (28, 56) 42 (28, 56) 42 (28, 56) 42 (28, 56) 42 (28, 56) 42 (28, 56)
PI3K+ TC2 n 13 (7, 26) 16 (10, 30) 15 (8, 29) 11 (6, 21) 0 (0, 0) 2 (0, 5) 3 (0, 6) 0 (0, 0)
PI3K+ TC2 post_p 0.35 (0.12, 0.48) 0.27 (0.07, 0.43) 0.32 (0.07, 0.46) 0.33 (0.1, 0.46) NA (NA, NA) 0.46 (0.36, 0.5) 0.45 (0.31, 0.49) NA (NA, NA)
PI3K+ TC2 r_prob 0.07 (0.07, 0.07) 0.27 (0.27, 0.27) 0.27 (0.27, 0.27) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 rate 0.026 (0.018, 0.045) 0.027 (0.018, 0.04) 0.027 (0.018, 0.046) 0.027 (0.019, 0.045) 0.085 (0.085, 0.085) 0.028 (0.001, 0.087) 0.031 (0, 0.075) 0 (0, 0)
PI3K+ TC3 count 45 45 45 45 45 45 45 45
PI3K+ TC3 time 40 (30, 54) 40 (30, 54) 40 (30, 54) 40 (30, 54) 40 (30, 54) 40 (30, 54) 40 (30, 54) 40 (30, 54)
PI3K+ TC3 n 12 (8, 26) 18 (9, 31) 15 (8, 30) 10 (5, 24) 0 (0, 0) 3 (1, 5) 4 (2, 6) 0 (0, 0)
PI3K+ TC3 post_p 0.37 (0.16, 0.47) 0.37 (0.12, 0.49) 0.31 (0.15, 0.47) 0.38 (0.22, 0.46) NA (NA, NA) 0.44 (0.32, 0.49) 0.44 (0.29, 0.5) NA (NA, NA)
PI3K+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC3 rate 0.026 (0.018, 0.038) 0.024 (0.017, 0.04) 0.026 (0.018, 0.041) 0.028 (0.018, 0.056) NA (NA, NA) 0.034 (0.009, 0.091) 0.029 (0.016, 0.084) 0 (0, 0)