Simulation scenario 5, HS phase

Setting description

TC4 more effective in the PI3K+ biomarker signature

Simulations setting

Survival curves (by signature)

PFS distributions (by signature)

Treatment effects (by signature)

signature	var	Other	TC1	TC2	TC3	TC4
all	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.02, shape = 1.3
all	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 46.8, median = 38.2
all	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 1.2, hr = 0.79
HRD+	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.022, shape = 1.3
HRD+	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 42.7, median = 34.9
HRD+	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 1.09, hr = 0.89
TP53+	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.019, shape = 1.3
TP53+	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 49.2, median = 40.2
TP53+	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 1.26, hr = 0.74
TEfus+	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.018, shape = 1.3
TEfus+	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 52.7, median = 43
TEfus+	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 1.35, hr = 0.68
PI3K+	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.012, shape = 1.3
PI3K+	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 78.1, median = 63.8
PI3K+	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 2, hr = 0.41

Survival curves (by subgroup)

PFS distributions (by subgroup)

Treatment effects (by subgroup)

subtype	var	Other	TC1	TC2	TC3	TC4
—-	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
—-	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 39, median = 31.9
—-	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 1, hr = 1
—+	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.012, shape = 1.3
—+	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 78.1, median = 63.8
—+	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 2, hr = 0.41
–+-	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
–+-	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 39, median = 31.9
–+-	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 1, hr = 1
–++	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.012, shape = 1.3
–++	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 78.1, median = 63.8
–++	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 2, hr = 0.41
-+–	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
-+–	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 39, median = 31.9
-+–	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 1, hr = 1
-+-+	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.012, shape = 1.3
-+-+	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 78.1, median = 63.8
-+-+	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 2, hr = 0.41
-++-	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
-++-	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 39, median = 31.9
-++-	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 1, hr = 1
-+++	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.012, shape = 1.3
-+++	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 78.1, median = 63.8
-+++	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 2, hr = 0.41
+—	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
+—	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 39, median = 31.9
+—	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 1, hr = 1
+–+	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.012, shape = 1.3
+–+	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 78.1, median = 63.8
+–+	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 2, hr = 0.41
+-+-	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
+-+-	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 39, median = 31.9
+-+-	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 1, hr = 1
+-++	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.012, shape = 1.3
+-++	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 78.1, median = 63.8
+-++	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 2, hr = 0.41
++–	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
++–	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 39, median = 31.9
++–	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 1, hr = 1
++-+	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.012, shape = 1.3
++-+	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 78.1, median = 63.8
++-+	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 2, hr = 0.41
+++-	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
+++-	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 39, median = 31.9
+++-	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 1, hr = 1
++++	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.012, shape = 1.3
++++	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 78.1, median = 63.8
++++	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 2, hr = 0.41

Errors and power

graduation (counts and proportions):

TC1 TC2 TC3 TC4 all 1 4 25 129 HRD+ 9 14 28 37 TP53+ 5 4 26 147 TEfus+ 0 1 14 109 PI3K+ 1 2 9 377

TC1 TC2 TC3 TC4 all 0.002 0.008 0.050 0.258 HRD+ 0.018 0.028 0.056 0.074 TP53+ 0.010 0.008 0.052 0.294 TEfus+ 0.000 0.002 0.028 0.218 PI3K+ 0.002 0.004 0.018 0.754

futility (counts and proportions):

TC1 TC2 TC3 TC4 all 19 24 2 0 HRD+ 12 8 9 0 TP53+ 139 166 37 0 TEfus+ 96 90 31 0 PI3K+ 144 119 45 0

TC1 TC2 TC3 TC4 all 0.038 0.048 0.004 0 HRD+ 0.024 0.016 0.018 0 TP53+ 0.278 0.332 0.074 0 TEfus+ 0.192 0.180 0.062 0 PI3K+ 0.288 0.238 0.090 0

max sample size (counts and proportions):

TC1 TC2 TC3 TC4 all 0 0 0 0 HRD+ 0 0 0 0 TP53+ 0 0 0 0 TEfus+ 0 0 0 0 PI3K+ 0 0 0 0

TC1 TC2 TC3 TC4 all 0 0 0 0 HRD+ 0 0 0 0 TP53+ 0 0 0 0 TEfus+ 0 0 0 0 PI3K+ 0 0 0 0

Operating characteristics

Characteristics	Overall	TC1	TC2	TC3	TC4
Error signature	0.376	0.03	0.046	0.184	0.184
Error subgroup	0.728	0.03	0.046	0.184	0.620
Power signature	0.754	0.00	0.000	0.000	0.754
Power subgroup	0.938	0.00	0.000	0.000	0.938

Median results at the end of the trial

By signature:

signature	var	Control	TC1	TC2	TC3	TC4
all	graduation	0	1	4	25	129
all	futility	0	19	24	2	0
all	max_n	0	0	0	0	0
all	n	627 (577, 690)	261 (181, 371)	274 (182, 366)	366 (240, 468)	266 (88, 397)
all	n_unique	627 (577, 690)	261 (181, 371)	274 (182, 366)	366 (240, 468)	266 (88, 397)
all	time_trial	60 (60, 60)	60 (60, 60)	60 (60, 60)	60 (60, 60)	60 (17, 60)
all	time_stop	NA (NA, NA)	34 (18, 52)	32 (12, 56)	15 (11, 33)	20 (12, 50)
all	post_p	NA (NA, NA)	0.26 (0.03, 0.74)	0.31 (0.04, 0.76)	0.86 (0.42, 0.99)	1 (1, 1)
all	rate	0.023 (0.022, 0.025)	0.025 (0.023, 0.028)	0.025 (0.022, 0.028)	0.021 (0.019, 0.023)	0.016 (0.014, 0.018)
HRD+	graduation	0	9	14	28	37
HRD+	futility	0	12	8	9	0
HRD+	max_n	0	0	0	0	0
HRD+	n	85 (72, 100)	42 (27, 61)	41 (25, 61)	52 (32, 72)	38 (11, 56)
HRD+	n_unique	85 (72, 100)	42 (27, 61)	41 (25, 61)	52 (32, 72)	38 (11, 56)
HRD+	time_trial	60 (60, 60)	60 (60, 60)	60 (60, 60)	60 (60, 60)	60 (60, 60)
HRD+	time_stop	NA (NA, NA)	52 (39, 58)	52 (47, 57)	51 (39, 57)	51 (45, 57)
HRD+	post_p	NA (NA, NA)	0.41 (0.09, 0.79)	0.41 (0.08, 0.82)	0.64 (0.18, 0.94)	0.82 (0.37, 0.98)
HRD+	rate	0.023 (0.019, 0.028)	0.025 (0.019, 0.033)	0.025 (0.019, 0.033)	0.022 (0.017, 0.028)	0.018 (0.012, 0.025)
TP53+	graduation	0	5	4	26	147
TP53+	futility	0	139	166	37	0
TP53+	max_n	0	0	0	0	0
TP53+	n	236 (209, 265)	100 (54, 156)	98 (52, 153)	131 (70, 192)	89 (36, 150)
TP53+	n_unique	236 (209, 265)	100 (54, 156)	98 (52, 153)	131 (70, 192)	89 (36, 150)
TP53+	time_trial	60 (60, 60)	60 (35, 60)	60 (27, 60)	60 (49, 60)	60 (32, 60)
TP53+	time_stop	NA (NA, NA)	39 (27, 55)	33 (22, 51)	40 (26, 53)	36 (26, 55)
TP53+	post_p	NA (NA, NA)	0.34 (0.06, 0.76)	0.34 (0.05, 0.78)	0.74 (0.28, 0.96)	1 (0.94, 1)
TP53+	rate	0.023 (0.02, 0.026)	0.025 (0.021, 0.031)	0.025 (0.021, 0.031)	0.021 (0.018, 0.025)	0.015 (0.012, 0.018)
TEfus+	graduation	0	0	1	14	109
TEfus+	futility	0	96	90	31	0
TEfus+	max_n	0	0	0	0	0
TEfus+	n	203 (179, 232)	88 (53, 133)	92 (52, 138)	114 (64, 161)	80 (30, 129)
TEfus+	n_unique	203 (179, 232)	88 (53, 133)	92 (52, 138)	114 (64, 161)	80 (30, 129)
TEfus+	time_trial	60 (60, 60)	60 (45, 60)	60 (43, 60)	60 (60, 60)	60 (35, 60)
TEfus+	time_stop	NA (NA, NA)	45 (32, 56)	40 (27, 59)	45 (32, 57)	36 (24, 55)
TEfus+	post_p	NA (NA, NA)	0.33 (0.04, 0.74)	0.35 (0.05, 0.81)	0.69 (0.23, 0.97)	1 (0.96, 1)
TEfus+	rate	0.023 (0.02, 0.026)	0.025 (0.021, 0.031)	0.025 (0.021, 0.031)	0.021 (0.017, 0.025)	0.013 (0.011, 0.017)
PI3K+	graduation	0	1	2	9	377
PI3K+	futility	0	144	119	45	0
PI3K+	max_n	0	0	0	0	0
PI3K+	n	222 (196, 248)	88 (53, 145)	91 (52, 140)	123 (63, 179)	90 (42, 157)
PI3K+	n_unique	222 (196, 248)	88 (53, 145)	91 (52, 140)	123 (63, 179)	90 (42, 157)
PI3K+	time_trial	60 (60, 60)	60 (37, 60)	60 (39, 60)	60 (57, 60)	40 (27, 60)
PI3K+	time_stop	NA (NA, NA)	42 (32, 54)	42 (28, 56)	39 (29, 56)	36 (26, 50)
PI3K+	post_p	NA (NA, NA)	0.3 (0.05, 0.75)	0.34 (0.05, 0.8)	0.71 (0.23, 0.95)	1 (1, 1)
PI3K+	rate	0.023 (0.02, 0.026)	0.025 (0.021, 0.031)	0.025 (0.021, 0.03)	0.021 (0.018, 0.025)	0.009 (0.007, 0.012)

By subgroup combinations:

subtype	var	Control	TC1	TC2	TC3	TC4
—-	graduation	0	1	4	25	129
—-	futility	0	19	24	2	0
—-	max_n	0	0	0	0	0
—-	n	191 (159, 227)	62 (28, 143)	67 (26, 154)	114 (31, 185)	74 (19, 168)
—-	n_unique	191 (159, 227)	62 (28, 143)	67 (26, 154)	114 (31, 185)	74 (19, 168)
—-	post_p	NA (NA, NA)	0.33 (0.07, 0.77)	0.38 (0.07, 0.81)	0.72 (0.21, 0.97)	0.65 (0.2, 0.96)
—-	rate	0.023 (0.02, 0.026)	0.026 (0.021, 0.034)	0.026 (0.021, 0.034)	0.021 (0.017, 0.028)	0.022 (0.017, 0.03)
—+	graduation	0	2	6	32	449
—+	futility	0	152	131	47	0
—+	max_n	0	0	0	0	0
—+	n	45 (35, 55)	16 (8, 37)	16 (7, 37)	23 (8, 45)	18 (8, 37)
—+	n_unique	45 (35, 55)	16 (8, 37)	16 (7, 37)	23 (8, 45)	18 (8, 37)
—+	post_p	NA (NA, NA)	0.33 (0.08, 0.76)	0.36 (0.09, 0.77)	0.54 (0.16, 0.88)	0.98 (0.8, 1)
—+	rate	0.023 (0.017, 0.03)	0.027 (0.018, 0.043)	0.026 (0.017, 0.042)	0.021 (0.014, 0.035)	0.009 (0.004, 0.015)
–+-	graduation	0	1	5	39	209
–+-	futility	0	106	104	32	0
–+-	max_n	0	0	0	0	0
–+-	n	13 (8, 18)	7 (3, 13)	7 (3, 13)	7 (3, 13)	5 (1, 11)
–+-	n_unique	13 (8, 18)	7 (3, 13)	7 (3, 13)	7 (3, 13)	5 (1, 11)
–+-	post_p	NA (NA, NA)	0.45 (0.19, 0.77)	0.43 (0.17, 0.76)	0.53 (0.24, 0.83)	0.54 (0.25, 0.81)
–+-	rate	0.023 (0.012, 0.036)	0.026 (0.011, 0.052)	0.026 (0.013, 0.052)	0.022 (0.007, 0.046)	0.021 (0.006, 0.049)
–++	graduation	0	2	7	46	457
–++	futility	0	196	182	71	0
–++	max_n	0	0	0	0	0
–++	n	67 (54, 82)	21 (10, 54)	21 (11, 53)	35 (10, 63)	27 (10, 51)
–++	n_unique	67 (54, 82)	21 (10, 54)	21 (11, 53)	35 (10, 63)	27 (10, 51)
–++	post_p	NA (NA, NA)	0.35 (0.07, 0.74)	0.33 (0.08, 0.78)	0.54 (0.14, 0.89)	0.99 (0.9, 1)
–++	rate	0.023 (0.019, 0.028)	0.026 (0.019, 0.039)	0.026 (0.018, 0.039)	0.021 (0.015, 0.033)	0.01 (0.006, 0.014)
-+–	graduation	0	6	7	50	247
-+–	futility	0	147	176	38	0
-+–	max_n	0	0	0	0	0
-+–	n	82 (66, 99)	29 (13, 73)	30 (15, 67)	45 (16, 78)	26 (9, 64)
-+–	n_unique	82 (66, 99)	29 (13, 73)	30 (15, 67)	45 (16, 78)	26 (9, 64)
-+–	post_p	NA (NA, NA)	0.42 (0.09, 0.83)	0.37 (0.09, 0.82)	0.63 (0.15, 0.94)	0.65 (0.2, 0.93)
-+–	rate	0.023 (0.019, 0.028)	0.026 (0.019, 0.038)	0.027 (0.02, 0.036)	0.021 (0.016, 0.032)	0.022 (0.015, 0.033)
-+-+	graduation	0	6	8	55	463
-+-+	futility	0	225	236	73	0
-+-+	max_n	0	0	0	0	0
-+-+	n	56 (43, 68)	18 (8, 46)	18 (8, 45)	27 (9, 54)	21 (9, 44)
-+-+	n_unique	56 (43, 68)	18 (8, 46)	18 (8, 45)	27 (9, 54)	21 (9, 44)
-+-+	post_p	NA (NA, NA)	0.34 (0.08, 0.73)	0.35 (0.07, 0.78)	0.54 (0.17, 0.89)	0.98 (0.86, 1)
-+-+	rate	0.023 (0.018, 0.03)	0.026 (0.019, 0.041)	0.027 (0.018, 0.04)	0.021 (0.014, 0.033)	0.009 (0.005, 0.015)
-++-	graduation	0	6	8	62	288
-++-	futility	0	200	221	63	0
-++-	max_n	0	0	0	0	0
-++-	n	50 (38, 61)	19 (8, 42)	19 (9, 45)	26 (9, 48)	14 (5, 32)
-++-	n_unique	50 (38, 61)	19 (8, 42)	19 (9, 45)	26 (9, 48)	14 (5, 32)
-++-	post_p	NA (NA, NA)	0.41 (0.1, 0.8)	0.43 (0.1, 0.83)	0.6 (0.18, 0.91)	0.56 (0.17, 0.88)
-++-	rate	0.022 (0.017, 0.029)	0.026 (0.017, 0.042)	0.026 (0.018, 0.04)	0.022 (0.014, 0.033)	0.022 (0.014, 0.037)
-+++	graduation	0	6	9	67	467
-+++	futility	0	259	269	93	0
-+++	max_n	0	0	0	0	0
-+++	n	38 (29, 48)	13 (6, 31)	13 (6, 33)	21 (7, 38)	14 (6, 28)
-+++	n_unique	38 (29, 48)	13 (6, 31)	13 (6, 33)	21 (7, 38)	14 (6, 28)
-+++	post_p	NA (NA, NA)	0.34 (0.07, 0.71)	0.38 (0.1, 0.75)	0.56 (0.17, 0.87)	0.95 (0.71, 1)
-+++	rate	0.022 (0.016, 0.031)	0.027 (0.017, 0.042)	0.026 (0.017, 0.042)	0.02 (0.013, 0.035)	0.01 (0.004, 0.017)
+—	graduation	0	10	18	53	160
+—	futility	0	31	32	11	0
+—	max_n	0	0	0	0	0
+—	n	40 (31, 51)	18 (8, 35)	18 (7, 33)	22 (10, 40)	17 (4, 34)
+—	n_unique	40 (31, 51)	18 (8, 35)	18 (7, 33)	22 (10, 40)	17 (4, 34)
+—	post_p	NA (NA, NA)	0.44 (0.13, 0.82)	0.4 (0.11, 0.82)	0.56 (0.17, 0.93)	0.57 (0.19, 0.9)
+—	rate	0.023 (0.017, 0.031)	0.025 (0.016, 0.041)	0.026 (0.017, 0.044)	0.022 (0.015, 0.035)	0.022 (0.013, 0.037)
+–+	graduation	0	10	20	59	451
+–+	futility	0	160	135	53	0
+–+	max_n	0	0	0	0	0
+–+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+–+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+–+	post_p	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
+–+	rate	0.03 (0.006, 0.045)	0 (0, 0)	0.085 (0.085, 0.085)	0 (0, 0)	0.015 (0.003, 0.026)
+-+-	graduation	0	10	19	66	234
+-+-	futility	0	116	110	41	0
+-+-	max_n	0	0	0	0	0
+-+-	n	29 (22, 37)	12 (6, 24)	12 (5, 26)	17 (7, 30)	10 (3, 23)
+-+-	n_unique	29 (22, 37)	12 (6, 24)	12 (5, 26)	17 (7, 30)	10 (3, 23)
+-+-	post_p	NA (NA, NA)	0.41 (0.11, 0.77)	0.45 (0.13, 0.82)	0.58 (0.19, 0.9)	0.56 (0.19, 0.88)
+-+-	rate	0.023 (0.016, 0.033)	0.027 (0.016, 0.047)	0.025 (0.015, 0.044)	0.022 (0.014, 0.037)	0.022 (0.012, 0.042)
+-++	graduation	0	10	21	72	459
+-++	futility	0	204	184	77	0
+-++	max_n	0	0	0	0	0
+-++	n	6 (3, 10)	4 (1, 7)	4 (1, 7)	4 (1, 8)	2 (0, 5)
+-++	n_unique	6 (3, 10)	4 (1, 7)	4 (1, 7)	4 (1, 8)	2 (0, 5)
+-++	post_p	NA (NA, NA)	0.46 (0.3, 0.66)	0.48 (0.3, 0.65)	0.47 (0.29, 0.67)	0.6 (0.46, 0.77)
+-++	rate	0.023 (0.006, 0.049)	0.025 (0.006, 0.071)	0.024 (0, 0.071)	0.022 (0.006, 0.061)	0.007 (0, 0.024)
++–	graduation	0	13	20	75	273
++–	futility	0	155	178	46	0
++–	max_n	0	0	0	0	0
++–	n	1 (0, 3)	1 (0, 2)	0 (0, 2)	1 (0, 2)	0 (0, 2)
++–	n_unique	1 (0, 3)	1 (0, 2)	0 (0, 2)	1 (0, 2)	0 (0, 2)
++–	post_p	NA (NA, NA)	0.5 (0.43, 0.56)	0.5 (0.44, 0.57)	0.49 (0.41, 0.57)	0.5 (0.43, 0.57)
++–	rate	0.021 (0, 0.101)	0.022 (0, 0.113)	0.024 (0, 0.112)	0.023 (0, 0.111)	0.017 (0, 0.096)
++-+	graduation	0	13	21	79	465
++-+	futility	0	231	236	79	0
++-+	max_n	0	0	0	0	0
++-+	n	8 (5, 13)	5 (2, 9)	4 (1, 9)	5 (2, 10)	3 (1, 7)
++-+	n_unique	8 (5, 13)	5 (2, 9)	4 (1, 9)	5 (2, 10)	3 (1, 7)
++-+	post_p	NA (NA, NA)	0.44 (0.23, 0.67)	0.45 (0.26, 0.69)	0.48 (0.26, 0.72)	0.62 (0.45, 0.84)
++-+	rate	0.023 (0.01, 0.043)	0.026 (0.008, 0.066)	0.025 (0.008, 0.062)	0.022 (0.009, 0.054)	0.009 (0, 0.026)
+++-	graduation	0	13	21	87	310
+++-	futility	0	207	222	71	0
+++-	max_n	0	0	0	0	0
+++-	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++-	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++-	post_p	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.47 (0.47, 0.48)	NA (NA, NA)
+++-	rate	0.028 (0.006, 0.035)	0 (0, 0.023)	NA (NA, NA)	0.087 (0, 0.157)	0.027 (0.023, 0.031)
++++	graduation	0	13	22	91	469
++++	futility	0	265	268	99	0
++++	max_n	0	0	0	0	0
++++	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++++	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++++	post_p	NA (NA, NA)	NA (NA, NA)	0.45 (0.45, 0.45)	0.44 (0.44, 0.44)	0.52 (0.52, 0.52)
++++	rate	0 (0, 0.323)	0.041 (0, 0.112)	0.02 (0, 0.069)	0 (0, 0.155)	0 (0, 0.113)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	TC1	TC2	TC3	TC4
all	count	1	4	25	129
all	time_stop	9 (9, 9)	14 (11, 19)	15 (11, 33)	20 (12, 50)
all	n_trt	60 (60, 60)	83 (70, 115)	70 (55, 210)	116 (57, 270)
all	n_control	81 (81, 81)	124 (88, 164)	128 (93, 296)	168 (94, 496)
all	post_p	0.89 (0.89, 0.89)	0.98 (0.98, 0.99)	0.93 (0.86, 1)	0.99 (0.9, 1)
all	order	1 (1, 1)	1 (1, 1)	1 (1, 2)	1 (1, 2.2)
HRD+	count	9	14	28	37
HRD+	time_stop	51 (37, 52)	50 (45, 56)	50 (39, 56)	51 (45, 57)
HRD+	n_trt	52 (50, 55)	52 (50, 56)	54 (50, 65)	53 (50, 64)
HRD+	n_control	66 (50, 76)	66 (51, 77)	65 (50, 85)	68 (51, 88)
HRD+	post_p	0.92 (0.89, 0.99)	0.96 (0.88, 0.99)	0.96 (0.87, 0.99)	0.97 (0.88, 0.99)
HRD+	order	2 (1.8, 3)	2 (1.3, 3.7)	2 (1, 3.3)	2 (1, 3)
TP53+	count	5	4	26	147
TP53+	time_stop	30 (19, 34)	28 (22, 36)	38 (24, 54)	36 (26, 55)
TP53+	n_trt	85 (52, 98)	60 (51, 81)	95 (56, 154)	80 (55, 120)
TP53+	n_control	108 (57, 123)	86 (77, 134)	138 (77, 198)	121 (76, 196)
TP53+	post_p	0.97 (0.92, 0.98)	0.95 (0.92, 0.98)	0.98 (0.92, 1)	1 (0.96, 1)
TP53+	order	2 (1, 2)	1.5 (1, 2.7)	2 (1, 3.5)	2 (1, 3)
TEfus+	count		1	14	109
TEfus+	time_stop		25 (25, 25)	52 (33, 58)	36 (24, 55)
TEfus+	n_trt		50 (50, 50)	102 (65, 167)	74 (51, 103)
TEfus+	n_control		64 (64, 64)	164 (96, 205)	99 (62, 177)
TEfus+	post_p		0.97 (0.97, 0.97)	0.98 (0.96, 1)	1 (0.96, 1)
TEfus+	order		1 (1, 1)	2 (2, 4)	2 (1, 3)
PI3K+	count	1	2	9	377
PI3K+	time_stop	31 (31, 31)	28 (27, 30)	34 (25, 58)	36 (26, 50)
PI3K+	n_trt	53 (53, 53)	66 (55, 77)	61 (53, 121)	92 (60, 141)
PI3K+	n_control	88 (88, 88)	94 (82, 107)	106 (74, 208)	109 (72, 168)
PI3K+	post_p	0.96 (0.96, 0.96)	0.99 (0.99, 1)	0.98 (0.92, 1)	1 (0.99, 1)
PI3K+	order	1 (1, 1)	2.5 (2.1, 2.9)	1 (1, 4)	1 (1, 3)

Futility:

signature	var	TC1	TC2	TC3
all	count	19	24	2
all	time_stop	36 (21, 52)	34 (14, 57)	24 (17, 30)
all	n_trt	135 (101, 193)	134 (69, 181)	107 (73, 141)
all	n_control	338 (172, 524)	324 (116, 584)	208 (143, 273)
all	post_p	0.04 (0, 0.09)	0.02 (0, 0.15)	0.02 (0.01, 0.04)
all	order	2 (1, 4)	2 (1, 5)	1 (1, 1)
HRD+	count	12	8	9
HRD+	time_stop	54 (48, 58)	54 (50, 58)	51 (44, 58)
HRD+	n_trt	57 (51, 62)	52 (50, 66)	62 (51, 64)
HRD+	n_control	72 (63, 86)	83 (67, 99)	78 (53, 99)
HRD+	post_p	0.23 (0.05, 0.27)	0.05 (0.02, 0.16)	0.26 (0.18, 0.3)
HRD+	order	2 (1.1, 4.8)	2.5 (1, 4.3)	2 (1, 2.2)
TP53+	count	139	166	37
TP53+	time_stop	40 (28, 55)	33 (22, 51)	41 (28, 52)
TP53+	n_trt	68 (50, 102)	62 (50, 96)	77 (55, 132)
TP53+	n_control	142 (90, 213)	113 (60, 198)	139 (88, 202)
TP53+	post_p	0.12 (0.03, 0.25)	0.13 (0.03, 0.25)	0.14 (0.04, 0.27)
TP53+	order	1 (1, 3)	1 (1, 2.5)	2 (1, 4)
TEfus+	count	96	90	31
TEfus+	time_stop	45 (32, 56)	40 (28, 59)	42 (33, 55)
TEfus+	n_trt	62 (50, 90)	58 (51, 95)	70 (53, 101)
TEfus+	n_control	143 (91, 185)	120 (76, 188)	125 (81, 189)
TEfus+	post_p	0.09 (0.02, 0.22)	0.1 (0.03, 0.26)	0.14 (0.05, 0.24)
TEfus+	order	2 (1, 4.5)	2 (1, 4)	2 (1, 4)
PI3K+	count	144	119	45
PI3K+	time_stop	42 (32, 54)	42 (28, 56)	40 (30, 54)
PI3K+	n_trt	62 (50, 92)	62 (51, 93)	64 (52, 101)
PI3K+	n_control	142 (86, 191)	138 (80, 203)	129 (90, 212)
PI3K+	post_p	0.09 (0.02, 0.23)	0.11 (0.02, 0.26)	0.12 (0.03, 0.22)
PI3K+	order	2 (1, 4)	2 (1, 4)	2 (1, 4)

By subgroup combinations

Graduation:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	TC1	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
all	TC1	time	9 (9, 9)	9 (9, 9)	9 (9, 9)	9 (9, 9)	9 (9, 9)	9 (9, 9)	9 (9, 9)	9 (9, 9)	9 (9, 9)	9 (9, 9)	9 (9, 9)	9 (9, 9)	9 (9, 9)	9 (9, 9)	9 (9, 9)	9 (9, 9)
all	TC1	n	30 (30, 30)	4 (4, 4)	2 (2, 2)	3 (3, 3)	6 (6, 6)	3 (3, 3)	3 (3, 3)	4 (4, 4)	2 (2, 2)	0 (0, 0)	2 (2, 2)	1 (1, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	post_p	0.68 (0.68, 0.68)	0.52 (0.52, 0.52)	NA (NA, NA)	0.51 (0.51, 0.51)	0.52 (0.52, 0.52)	0.52 (0.52, 0.52)	0.52 (0.52, 0.52)	0.51 (0.51, 0.51)	0.52 (0.52, 0.52)	NA (NA, NA)	0.53 (0.53, 0.53)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC1	r_prob	0.37 (0.37, 0.37)	0.27 (0.27, 0.27)	0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.06 (0.06, 0.06)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	rate	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0.332 (0.332, 0.332)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC2	count	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4
all	TC2	time	14 (11, 19)	14 (11, 19)	14 (11, 19)	14 (11, 19)	14 (11, 19)	14 (11, 19)	14 (11, 19)	14 (11, 19)	14 (11, 19)	14 (11, 19)	14 (11, 19)	14 (11, 19)	14 (11, 19)	14 (11, 19)	14 (11, 19)	14 (11, 19)
all	TC2	n	30 (22, 36)	5 (3, 6)	2 (0, 4)	10 (6, 13)	14 (10, 22)	8 (6, 11)	8 (6, 10)	4 (4, 5)	2 (1, 8)	0 (0, 0)	2 (2, 4)	0 (0, 1)	0 (0, 1)	1 (0, 1)	0 (0, 0)	0 (0, 0)
all	TC2	post_p	0.77 (0.66, 0.8)	0.53 (0.52, 0.54)	0.5 (0.5, 0.5)	0.53 (0.52, 0.68)	0.59 (0.57, 0.61)	0.57 (0.52, 0.61)	0.53 (0.52, 0.57)	0.56 (0.52, 0.61)	0.53 (0.51, 0.54)	NA (NA, NA)	0.53 (0.51, 0.55)	NA (NA, NA)	NA (NA, NA)	0.54 (0.54, 0.54)	NA (NA, NA)	NA (NA, NA)
all	TC2	r_prob	0.25 (0.25, 0.25)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.25 (0.25, 0.25)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	rate	0.002 (0, 0.011)	0 (0, 0)	0 (0, 0.017)	0.006 (0, 0.012)	0.002 (0, 0.006)	0.004 (0, 0.021)	0.014 (0.004, 0.022)	0 (0, 0)	0 (0, 0.012)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)
all	TC3	count	25	25	25	25	25	25	25	25	25	25	25	25	25	25	25	25
all	TC3	time	15 (11, 33)	15 (11, 33)	15 (11, 33)	15 (11, 33)	15 (11, 33)	15 (11, 33)	15 (11, 33)	15 (11, 33)	15 (11, 33)	15 (11, 33)	15 (11, 33)	15 (11, 33)	15 (11, 33)	15 (11, 33)	15 (11, 33)	15 (11, 33)
all	TC3	n	17 (11, 50)	4 (0, 14)	1 (0, 6)	7 (1, 24)	9 (4, 36)	7 (3, 16)	6 (3, 17)	4 (2, 15)	10 (5, 18)	0 (0, 0)	8 (3, 14)	1 (0, 2)	0 (0, 1)	1 (0, 5)	0 (0, 0)	0 (0, 0)
all	TC3	post_p	0.58 (0.54, 0.83)	0.54 (0.51, 0.63)	0.54 (0.51, 0.73)	0.56 (0.51, 0.65)	0.57 (0.52, 0.8)	0.53 (0.52, 0.71)	0.54 (0.52, 0.63)	0.53 (0.52, 0.6)	0.55 (0.51, 0.67)	NA (NA, NA)	0.55 (0.51, 0.67)	0.53 (0.5, 0.56)	NA (NA, NA)	0.52 (0.5, 0.55)	NA (NA, NA)	NA (NA, NA)
all	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
all	TC3	rate	0.005 (0, 0.019)	0 (0, 0.019)	0 (0, 0.006)	0 (0, 0.012)	0 (0, 0.014)	0 (0, 0.014)	0 (0, 0.02)	0 (0, 0.013)	0 (0, 0.016)	NA (NA, NA)	0 (0, 0.02)	0 (0, 0)	0 (0, 0)	0 (0, 0.012)	NA (NA, NA)	0.075 (0.073, 0.078)
all	TC4	count	129	129	129	129	129	129	129	129	129	129	129	129	129	129	129	129
all	TC4	time	20 (12, 50)	20 (12, 50)	20 (12, 50)	20 (12, 50)	20 (12, 50)	20 (12, 50)	20 (12, 50)	20 (12, 50)	20 (12, 50)	20 (12, 50)	20 (12, 50)	20 (12, 50)	20 (12, 50)	20 (12, 50)	20 (12, 50)	20 (12, 50)
all	TC4	n	30 (12, 93)	10 (5, 23)	2 (0, 5)	14 (7, 34)	13 (5, 32)	13 (7, 27)	8 (3, 18)	9 (3, 18)	6 (2, 21)	0 (0, 0)	4 (1, 13)	1 (0, 4)	0 (0, 1)	2 (0, 5)	0 (0, 0)	0 (0, 0)
all	TC4	post_p	0.68 (0.52, 0.9)	0.6 (0.52, 0.98)	0.54 (0.5, 0.66)	0.6 (0.53, 0.99)	0.57 (0.51, 0.81)	0.61 (0.52, 0.95)	0.56 (0.51, 0.76)	0.58 (0.52, 0.92)	0.55 (0.51, 0.82)	NA (NA, NA)	0.54 (0.51, 0.73)	0.53 (0.51, 0.6)	0.53 (0.52, 0.56)	0.54 (0.51, 0.63)	NA (NA, NA)	NA (NA, NA)
all	TC4	r_prob	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.31 (0.31, 0.31)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
all	TC4	rate	0.013 (0, 0.022)	0 (0, 0.013)	0 (0, 0.021)	0.007 (0, 0.013)	0.013 (0, 0.022)	0.005 (0, 0.015)	0 (0, 0.022)	0 (0, 0.015)	0 (0, 0.023)	0.029 (0.029, 0.029)	0 (0, 0.021)	0 (0, 0.014)	0 (0, 0)	0 (0, 0.014)	NA (NA, NA)	0 (0, 0)
HRD+	TC1	count									9	9	9	9	9	9	9	9
HRD+	TC1	time									51 (37, 52)	51 (37, 52)	51 (37, 52)	51 (37, 52)	51 (37, 52)	51 (37, 52)	51 (37, 52)	51 (37, 52)
HRD+	TC1	n									27 (18, 32)	0 (0, 0)	17 (11, 22)	4 (2, 7)	0 (0, 1)	4 (2, 10)	0 (0, 0)	0 (0, 0)
HRD+	TC1	post_p									0.83 (0.72, 0.93)	NA (NA, NA)	0.73 (0.67, 0.86)	0.53 (0.51, 0.58)	0.52 (0.51, 0.53)	0.61 (0.53, 0.9)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	rate									0.018 (0.015, 0.02)	NA (NA, NA)	0.015 (0.011, 0.029)	0 (0, 0.034)	0 (0, 0.042)	0 (0, 0.022)	NA (NA, NA)	NA (NA, NA)
HRD+	TC2	count									14	14	14	14	14	14	14	14
HRD+	TC2	time									50 (45, 56)	50 (45, 56)	50 (45, 56)	50 (45, 56)	50 (45, 56)	50 (45, 56)	50 (45, 56)	50 (45, 56)
HRD+	TC2	n									28 (20, 32)	0 (0, 0)	17 (13, 23)	4 (2, 7)	1 (0, 2)	5 (2, 8)	0 (0, 0)	0 (0, 0)
HRD+	TC2	post_p									0.81 (0.73, 0.91)	NA (NA, NA)	0.8 (0.71, 0.91)	0.56 (0.52, 0.66)	0.53 (0.52, 0.57)	0.56 (0.51, 0.68)	NA (NA, NA)	NA (NA, NA)
HRD+	TC2	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC2	rate									0.018 (0.013, 0.021)	NA (NA, NA)	0.015 (0.009, 0.02)	0.01 (0, 0.027)	0 (0, 0.066)	0.012 (0, 0.026)	NA (NA, NA)	NA (NA, NA)
HRD+	TC3	count									28	28	28	28	28	28	28	28
HRD+	TC3	time									50 (39, 56)	50 (39, 56)	50 (39, 56)	50 (39, 56)	50 (39, 56)	50 (39, 56)	50 (39, 56)	50 (39, 56)
HRD+	TC3	n									26 (19, 38)	0 (0, 0)	22 (13, 27)	4 (2, 5)	0 (0, 1)	5 (3, 8)	0 (0, 0)	0 (0, 0)
HRD+	TC3	post_p									0.84 (0.72, 0.96)	NA (NA, NA)	0.81 (0.71, 0.88)	0.53 (0.51, 0.63)	0.51 (0.51, 0.56)	0.55 (0.51, 0.65)	0.52 (0.52, 0.52)	NA (NA, NA)
HRD+	TC3	r_prob									0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
HRD+	TC3	rate									0.015 (0.009, 0.022)	NA (NA, NA)	0.017 (0.012, 0.023)	0.005 (0, 0.024)	0 (0, 0.063)	0.015 (0, 0.021)	0.166 (0.118, 0.215)	NA (NA, NA)
HRD+	TC4	count									37	37	37	37	37	37	37	37
HRD+	TC4	time									51 (45, 57)	51 (45, 57)	51 (45, 57)	51 (45, 57)	51 (45, 57)	51 (45, 57)	51 (45, 57)	51 (45, 57)
HRD+	TC4	n									28 (24, 37)	0 (0, 0)	17 (10, 26)	4 (1, 7)	0 (0, 2)	4 (1, 8)	0 (0, 0)	0 (0, 0)
HRD+	TC4	post_p									0.79 (0.71, 0.95)	NA (NA, NA)	0.8 (0.57, 0.96)	0.57 (0.52, 0.69)	0.53 (0.5, 0.56)	0.6 (0.54, 0.82)	NA (NA, NA)	NA (NA, NA)
HRD+	TC4	r_prob									0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
HRD+	TC4	rate									0.015 (0.01, 0.019)	NA (NA, NA)	0.015 (0.007, 0.022)	0.007 (0, 0.018)	0 (0, 0.083)	0 (0, 0.011)	0.016 (0.003, 0.029)	0 (0, 0)
TP53+	TC1	count					5	5	5	5					5	5	5	5
TP53+	TC1	time					30 (19, 34)	30 (19, 34)	30 (19, 34)	30 (19, 34)					30 (19, 34)	30 (19, 34)	30 (19, 34)	30 (19, 34)
TP53+	TC1	n					19 (17, 32)	10 (9, 27)	22 (13, 25)	14 (10, 20)					0 (0, 1)	3 (1, 7)	0 (0, 0)	0 (0, 0)
TP53+	TC1	post_p					0.77 (0.75, 0.87)	0.6 (0.59, 0.81)	0.77 (0.73, 0.82)	0.71 (0.52, 0.82)					NA (NA, NA)	0.53 (0.51, 0.53)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	r_prob					0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.06 (0.06, 0.06)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	rate					0.01 (0.006, 0.014)	0.008 (0, 0.014)	0.009 (0.003, 0.016)	0.007 (0, 0.016)					0 (0, 0)	0.008 (0, 0.027)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	count					4	4	4	4					4	4	4	4
TP53+	TC2	time					28 (22, 36)	28 (22, 36)	28 (22, 36)	28 (22, 36)					28 (22, 36)	28 (22, 36)	28 (22, 36)	28 (22, 36)
TP53+	TC2	n					25 (25, 38)	16 (8, 23)	9 (9, 10)	9 (5, 10)					0 (0, 1)	1 (0, 2)	0 (0, 0)	0 (0, 0)
TP53+	TC2	post_p					0.8 (0.75, 0.87)	0.82 (0.59, 0.87)	0.52 (0.5, 0.59)	0.58 (0.55, 0.64)					0.54 (0.54, 0.54)	0.53 (0.51, 0.53)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	r_prob					0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.25 (0.25, 0.25)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	rate					0.011 (0.006, 0.013)	0.011 (0.005, 0.016)	0.016 (0.004, 0.021)	0.009 (0.007, 0.012)					0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	count					26	26	26	26					26	26	26	26
TP53+	TC3	time					38 (24, 54)	38 (24, 54)	38 (24, 54)	38 (24, 54)					38 (24, 54)	38 (24, 54)	38 (24, 54)	38 (24, 54)
TP53+	TC3	n					27 (20, 57)	20 (12, 38)	22 (10, 32)	14 (8, 24)					0 (0, 1)	4 (0, 7)	0 (0, 0)	0 (0, 0)
TP53+	TC3	post_p					0.84 (0.72, 0.95)	0.75 (0.71, 0.9)	0.77 (0.59, 0.86)	0.73 (0.54, 0.85)					0.53 (0.51, 0.6)	0.55 (0.51, 0.6)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	r_prob					0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)					0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
TP53+	TC3	rate					0.014 (0.002, 0.018)	0.012 (0.002, 0.017)	0.013 (0.004, 0.018)	0.013 (0, 0.017)					0.015 (0, 0.19)	0.016 (0, 0.032)	NA (NA, NA)	NA (NA, NA)
TP53+	TC4	count					147	147	147	147					147	147	147	147
TP53+	TC4	time					36 (26, 55)	36 (26, 55)	36 (26, 55)	36 (26, 55)					36 (26, 55)	36 (26, 55)	36 (26, 55)	36 (26, 55)
TP53+	TC4	n					25 (13, 45)	22 (13, 34)	15 (7, 28)	14 (8, 23)					0 (0, 1)	3 (1, 6)	0 (0, 0)	0 (0, 0)
TP53+	TC4	post_p					0.76 (0.7, 0.91)	0.9 (0.72, 0.99)	0.73 (0.54, 0.87)	0.78 (0.56, 0.98)					0.53 (0.51, 0.56)	0.56 (0.51, 0.65)	NA (NA, NA)	0.54 (0.54, 0.54)
TP53+	TC4	r_prob					0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.31 (0.31, 0.31)					0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
TP53+	TC4	rate					0.015 (0.006, 0.02)	0.008 (0.002, 0.013)	0.014 (0, 0.021)	0.007 (0, 0.013)					0 (0, 0.057)	0 (0, 0.019)	NA (NA, NA)	0 (0, 0.096)
TEfus+	TC2	count			1	1			1	1			1	1			1	1
TEfus+	TC2	time			25 (25, 25)	25 (25, 25)			25 (25, 25)	25 (25, 25)			25 (25, 25)	25 (25, 25)			25 (25, 25)	25 (25, 25)
TEfus+	TC2	n			3 (3, 3)	16 (16, 16)			18 (18, 18)	10 (10, 10)			2 (2, 2)	1 (1, 1)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	post_p			0.53 (0.53, 0.53)	0.71 (0.71, 0.71)			0.87 (0.87, 0.87)	0.52 (0.52, 0.52)			0.56 (0.56, 0.56)	0.55 (0.55, 0.55)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC2	r_prob			0.41 (0.41, 0.41)	0.27 (0.27, 0.27)			0.41 (0.41, 0.41)	0.25 (0.25, 0.25)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	rate			0 (0, 0)	0.006 (0.006, 0.006)			0.005 (0.005, 0.005)	0.011 (0.011, 0.011)			0 (0, 0)	0 (0, 0)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC3	count			14	14			14	14			14	14			14	14
TEfus+	TC3	time			52 (33, 58)	52 (33, 58)			52 (33, 58)	52 (33, 58)			52 (33, 58)	52 (33, 58)			52 (33, 58)	52 (33, 58)
TEfus+	TC3	n			5 (2, 10)	36 (18, 58)			24 (10, 38)	22 (7, 41)			16 (9, 25)	4 (2, 6)			0 (0, 0)	0 (0, 0)
TEfus+	TC3	post_p			0.6 (0.52, 0.81)	0.86 (0.74, 0.92)			0.8 (0.71, 0.95)	0.74 (0.6, 0.86)			0.74 (0.6, 0.94)	0.55 (0.51, 0.6)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC3	r_prob			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.5 (0.5, 0.5)	0.33 (0.33, 0.33)			0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
TEfus+	TC3	rate			0.016 (0, 0.025)	0.014 (0.01, 0.02)			0.014 (0.009, 0.02)	0.013 (0.01, 0.019)			0.015 (0.009, 0.023)	0.011 (0, 0.029)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC4	count			109	109			109	109			109	109			109	109
TEfus+	TC4	time			36 (24, 55)	36 (24, 55)			36 (24, 55)	36 (24, 55)			36 (24, 55)	36 (24, 55)			36 (24, 55)	36 (24, 55)
TEfus+	TC4	n			4 (2, 8)	28 (19, 41)			14 (7, 27)	14 (8, 22)			9 (4, 17)	3 (0, 5)			0 (0, 0)	0 (0, 0)
TEfus+	TC4	post_p			0.56 (0.51, 0.7)	0.92 (0.71, 1)			0.72 (0.53, 0.89)	0.8 (0.56, 0.98)			0.63 (0.51, 0.86)	0.55 (0.51, 0.63)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC4	r_prob			0 (0, 0)	0.33 (0.33, 0.33)			0 (0, 0)	0.31 (0.31, 0.31)			0 (0, 0)	0.33 (0.33, 0.33)			0 (0, 0)	0.33 (0.33, 0.33)
TEfus+	TC4	rate			0.009 (0, 0.025)	0.007 (0.002, 0.012)			0.012 (0, 0.022)	0.007 (0, 0.012)			0.011 (0, 0.024)	0 (0, 0.018)			NA (NA, NA)	0 (0, 0)
PI3K+	TC1	count		1		1		1		1		1		1		1		1
PI3K+	TC1	time		31 (31, 31)		31 (31, 31)		31 (31, 31)		31 (31, 31)		31 (31, 31)		31 (31, 31)		31 (31, 31)		31 (31, 31)
PI3K+	TC1	n		6 (6, 6)		17 (17, 17)		16 (16, 16)		8 (8, 8)		0 (0, 0)		3 (3, 3)		3 (3, 3)		0 (0, 0)
PI3K+	TC1	post_p		0.51 (0.51, 0.51)		0.79 (0.79, 0.79)		0.78 (0.78, 0.78)		0.68 (0.68, 0.68)		NA (NA, NA)		0.55 (0.55, 0.55)		0.54 (0.54, 0.54)		NA (NA, NA)
PI3K+	TC1	r_prob		0.27 (0.27, 0.27)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.06 (0.06, 0.06)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	rate		0.023 (0.023, 0.023)		0.006 (0.006, 0.006)		0.019 (0.019, 0.019)		0.007 (0.007, 0.007)		NA (NA, NA)		0 (0, 0)		0 (0, 0)		NA (NA, NA)
PI3K+	TC2	count		2		2		2		2		2		2		2		2
PI3K+	TC2	time		28 (27, 30)		28 (27, 30)		28 (27, 30)		28 (27, 30)		28 (27, 30)		28 (27, 30)		28 (27, 30)		28 (27, 30)
PI3K+	TC2	n		18 (16, 19)		16 (11, 22)		18 (9, 26)		9 (8, 10)		0 (0, 0)		4 (4, 5)		1 (1, 1)		0 (0, 0)
PI3K+	TC2	post_p		0.77 (0.73, 0.82)		0.63 (0.57, 0.69)		0.74 (0.62, 0.86)		0.68 (0.62, 0.74)		NA (NA, NA)		0.58 (0.57, 0.59)		0.55 (0.55, 0.55)		NA (NA, NA)
PI3K+	TC2	r_prob		0.07 (0.07, 0.07)		0.27 (0.27, 0.27)		0.27 (0.27, 0.27)		0.25 (0.25, 0.25)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	rate		0.006 (0.001, 0.011)		0.011 (0.008, 0.014)		0.007 (0.007, 0.008)		0.012 (0.011, 0.013)		NA (NA, NA)		0 (0, 0)		0 (0, 0)		NA (NA, NA)
PI3K+	TC3	count		9		9		9		9		9		9		9		9
PI3K+	TC3	time		34 (25, 58)		34 (25, 58)		34 (25, 58)		34 (25, 58)		34 (25, 58)		34 (25, 58)		34 (25, 58)		34 (25, 58)
PI3K+	TC3	n		20 (10, 30)		19 (9, 44)		18 (12, 26)		9 (7, 25)		0 (0, 0)		2 (1, 3)		3 (2, 6)		0 (0, 0)
PI3K+	TC3	post_p		0.73 (0.6, 0.81)		0.73 (0.59, 0.86)		0.8 (0.67, 0.92)		0.67 (0.53, 0.79)		NA (NA, NA)		0.56 (0.52, 0.62)		0.55 (0.51, 0.64)		NA (NA, NA)
PI3K+	TC3	r_prob		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC3	rate		0.013 (0.008, 0.022)		0.01 (0.003, 0.014)		0.006 (0, 0.018)		0.013 (0, 0.021)		NA (NA, NA)		0 (0, 0.015)		0.005 (0, 0.014)		0.078 (0.078, 0.078)
PI3K+	TC4	count		377		377		377		377		377		377		377		377
PI3K+	TC4	time		36 (26, 50)		36 (26, 50)		36 (26, 50)		36 (26, 50)		36 (26, 50)		36 (26, 50)		36 (26, 50)		36 (26, 50)
PI3K+	TC4	n		18 (9, 34)		28 (17, 48)		22 (13, 40)		15 (8, 27)		0 (0, 0)		3 (1, 5)		3 (1, 7)		0 (0, 0)
PI3K+	TC4	post_p		0.82 (0.65, 0.99)		0.9 (0.71, 1)		0.86 (0.71, 0.99)		0.76 (0.56, 0.96)		NA (NA, NA)		0.54 (0.51, 0.63)		0.55 (0.51, 0.69)		0.54 (0.54, 0.54)
PI3K+	TC4	r_prob		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.31 (0.31, 0.31)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC4	rate		0.007 (0, 0.014)		0.008 (0.002, 0.014)		0.008 (0, 0.014)		0.008 (0, 0.014)		0.029 (0.029, 0.029)		0 (0, 0.021)		0 (0, 0.019)		0 (0, 0.029)

Futility:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	TC1	count	19	19	19	19	19	19	19	19	19	19	19	19	19	19	19	19
all	TC1	time	36 (21, 52)	36 (21, 52)	36 (21, 52)	36 (21, 52)	36 (21, 52)	36 (21, 52)	36 (21, 52)	36 (21, 52)	36 (21, 52)	36 (21, 52)	36 (21, 52)	36 (21, 52)	36 (21, 52)	36 (21, 52)	36 (21, 52)	36 (21, 52)
all	TC1	n	36 (24, 60)	14 (7, 21)	4 (2, 8)	12 (4, 20)	16 (9, 24)	10 (4, 17)	13 (5, 20)	7 (3, 13)	8 (3, 13)	0 (0, 0)	8 (4, 13)	1 (0, 3)	0 (0, 1)	3 (1, 4)	0 (0, 0)	0 (0, 0)
all	TC1	post_p	0.28 (0.06, 0.45)	0.38 (0.11, 0.46)	0.41 (0.21, 0.49)	0.33 (0.14, 0.47)	0.34 (0.09, 0.45)	0.32 (0.09, 0.47)	0.38 (0.12, 0.49)	0.37 (0.24, 0.46)	0.39 (0.17, 0.49)	NA (NA, NA)	0.4 (0.23, 0.5)	0.46 (0.37, 0.47)	0.49 (0.49, 0.5)	0.42 (0.37, 0.48)	NA (NA, NA)	NA (NA, NA)
all	TC1	r_prob	0.37 (0.37, 0.37)	0.27 (0.27, 0.27)	0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.06 (0.06, 0.06)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	rate	0.027 (0.02, 0.037)	0.027 (0.019, 0.036)	0.036 (0.016, 0.07)	0.031 (0.02, 0.048)	0.028 (0.023, 0.039)	0.032 (0.016, 0.063)	0.028 (0.019, 0.048)	0.03 (0.021, 0.051)	0.031 (0.012, 0.069)	NA (NA, NA)	0.025 (0.013, 0.051)	0.039 (0.011, 0.093)	0 (0, 0.07)	0.034 (0, 0.098)	NA (NA, NA)	0 (0, 0)
all	TC2	count	24	24	24	24	24	24	24	24	24	24	24	24	24	24	24	24
all	TC2	time	34 (14, 57)	34 (14, 57)	34 (14, 57)	34 (14, 57)	34 (14, 57)	34 (14, 57)	34 (14, 57)	34 (14, 57)	34 (14, 57)	34 (14, 57)	34 (14, 57)	34 (14, 57)	34 (14, 57)	34 (14, 57)	34 (14, 57)	34 (14, 57)
all	TC2	n	28 (20, 61)	9 (2, 18)	5 (0, 9)	14 (7, 22)	17 (10, 34)	10 (7, 17)	12 (7, 21)	6 (4, 12)	8 (2, 14)	0 (0, 0)	6 (2, 10)	2 (0, 5)	0 (0, 1)	1 (0, 6)	0 (0, 0)	0 (0, 0)
all	TC2	post_p	0.27 (0.07, 0.42)	0.39 (0.23, 0.47)	0.4 (0.29, 0.49)	0.26 (0.08, 0.43)	0.31 (0.17, 0.45)	0.35 (0.12, 0.43)	0.31 (0.09, 0.49)	0.31 (0.12, 0.45)	0.31 (0.1, 0.49)	NA (NA, NA)	0.42 (0.17, 0.49)	0.47 (0.4, 0.49)	0.47 (0.46, 0.48)	0.45 (0.34, 0.49)	NA (NA, NA)	NA (NA, NA)
all	TC2	r_prob	0.25 (0.25, 0.25)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.25 (0.25, 0.25)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	rate	0.027 (0.022, 0.036)	0.026 (0.017, 0.047)	0.023 (0.011, 0.068)	0.027 (0.018, 0.038)	0.025 (0.019, 0.034)	0.032 (0.018, 0.054)	0.029 (0.015, 0.041)	0.033 (0.022, 0.067)	0.034 (0.005, 0.053)	0.085 (0.085, 0.085)	0.038 (0.016, 0.075)	0.018 (0, 0.058)	0.04 (0, 0.53)	0.024 (0, 0.135)	NA (NA, NA)	NA (NA, NA)
all	TC3	count	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2
all	TC3	time	24 (17, 30)	24 (17, 30)	24 (17, 30)	24 (17, 30)	24 (17, 30)	24 (17, 30)	24 (17, 30)	24 (17, 30)	24 (17, 30)	24 (17, 30)	24 (17, 30)	24 (17, 30)	24 (17, 30)	24 (17, 30)	24 (17, 30)	24 (17, 30)
all	TC3	n	28 (20, 37)	6 (4, 7)	2 (1, 2)	10 (6, 14)	14 (10, 19)	5 (4, 6)	10 (6, 14)	8 (4, 12)	12 (8, 16)	0 (0, 0)	8 (6, 9)	2 (0, 3)	0 (0, 1)	2 (2, 3)	0 (0, 0)	0 (0, 0)
all	TC3	post_p	0.33 (0.31, 0.34)	0.3 (0.19, 0.4)	0.39 (0.32, 0.47)	0.34 (0.3, 0.37)	0.3 (0.25, 0.34)	0.39 (0.38, 0.39)	0.38 (0.36, 0.39)	0.46 (0.44, 0.48)	0.42 (0.36, 0.47)	NA (NA, NA)	0.39 (0.31, 0.47)	0.49 (0.49, 0.49)	0.46 (0.46, 0.46)	0.42 (0.42, 0.42)	NA (NA, NA)	NA (NA, NA)
all	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
all	TC3	rate	0.027 (0.022, 0.031)	0.05 (0.046, 0.055)	0.122 (0.024, 0.219)	0.044 (0.032, 0.056)	0.036 (0.035, 0.038)	0.059 (0.035, 0.083)	0.03 (0.019, 0.04)	0.008 (0.002, 0.015)	0.024 (0.02, 0.028)	NA (NA, NA)	0.029 (0.023, 0.034)	0.026 (0.026, 0.026)	0 (0, 0)	0.017 (0.003, 0.031)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	count									12	12	12	12	12	12	12	12
HRD+	TC1	time									54 (48, 58)	54 (48, 58)	54 (48, 58)	54 (48, 58)	54 (48, 58)	54 (48, 58)	54 (48, 58)	54 (48, 58)
HRD+	TC1	n									31 (25, 40)	0 (0, 0)	16 (12, 22)	4 (2, 7)	0 (0, 2)	4 (2, 8)	0 (0, 0)	0 (0, 0)
HRD+	TC1	post_p									0.39 (0.26, 0.45)	NA (NA, NA)	0.34 (0.17, 0.46)	0.4 (0.36, 0.44)	0.48 (0.46, 0.49)	0.38 (0.3, 0.45)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	rate									0.025 (0.022, 0.028)	0 (0, 0)	0.028 (0.022, 0.035)	0.032 (0.024, 0.12)	0.051 (0.008, 0.91)	0.027 (0.021, 0.042)	NA (NA, NA)	NA (NA, NA)
HRD+	TC2	count									8	8	8	8	8	8	8	8
HRD+	TC2	time									54 (50, 58)	54 (50, 58)	54 (50, 58)	54 (50, 58)	54 (50, 58)	54 (50, 58)	54 (50, 58)	54 (50, 58)
HRD+	TC2	n									24 (18, 34)	0 (0, 0)	22 (17, 30)	4 (1, 6)	0 (0, 2)	4 (2, 7)	0 (0, 0)	0 (0, 0)
HRD+	TC2	post_p									0.16 (0.05, 0.48)	NA (NA, NA)	0.24 (0.08, 0.45)	0.44 (0.42, 0.49)	0.43 (0.42, 0.44)	0.42 (0.27, 0.49)	NA (NA, NA)	NA (NA, NA)
HRD+	TC2	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC2	rate									0.027 (0.021, 0.038)	NA (NA, NA)	0.032 (0.02, 0.038)	0.028 (0.016, 0.054)	0.013 (0.003, 0.078)	0.027 (0.02, 0.046)	NA (NA, NA)	0 (0, 0)
HRD+	TC3	count									9	9	9	9	9	9	9	9
HRD+	TC3	time									51 (44, 58)	51 (44, 58)	51 (44, 58)	51 (44, 58)	51 (44, 58)	51 (44, 58)	51 (44, 58)	51 (44, 58)
HRD+	TC3	n									27 (17, 34)	0 (0, 0)	22 (12, 31)	5 (2, 7)	1 (0, 3)	5 (4, 7)	0 (0, 0)	0 (0, 0)
HRD+	TC3	post_p									0.36 (0.18, 0.44)	NA (NA, NA)	0.4 (0.34, 0.47)	0.42 (0.39, 0.46)	0.45 (0.42, 0.48)	0.43 (0.31, 0.45)	NA (NA, NA)	NA (NA, NA)
HRD+	TC3	r_prob									0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
HRD+	TC3	rate									0.027 (0.022, 0.036)	NA (NA, NA)	0.025 (0.016, 0.03)	0.029 (0.014, 0.035)	0.025 (0.009, 0.095)	0.025 (0.02, 0.049)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	count					139	139	139	139					139	139	139	139
TP53+	TC1	time					40 (28, 55)	40 (28, 55)	40 (28, 55)	40 (28, 55)					40 (28, 55)	40 (28, 55)	40 (28, 55)	40 (28, 55)
TP53+	TC1	n					22 (13, 44)	13 (8, 30)	15 (7, 28)	11 (6, 20)					0 (0, 2)	3 (1, 6)	0 (0, 0)	0 (0, 0)
TP53+	TC1	post_p					0.35 (0.12, 0.47)	0.3 (0.08, 0.48)	0.36 (0.12, 0.48)	0.34 (0.14, 0.48)					0.46 (0.43, 0.49)	0.43 (0.29, 0.49)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	r_prob					0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.06 (0.06, 0.06)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	rate					0.026 (0.019, 0.039)	0.028 (0.019, 0.046)	0.027 (0.02, 0.045)	0.028 (0.02, 0.043)					0.008 (0, 0.114)	0.033 (0, 0.098)	NA (NA, NA)	0 (0, 0.775)
TP53+	TC2	count					166	166	166	166					166	166	166	166
TP53+	TC2	time					33 (22, 51)	33 (22, 51)	33 (22, 51)	33 (22, 51)					33 (22, 51)	33 (22, 51)	33 (22, 51)	33 (22, 51)
TP53+	TC2	n					22 (14, 38)	13 (8, 25)	14 (8, 28)	9 (5, 18)					0 (0, 1)	2 (0, 6)	0 (0, 0)	0 (0, 0)
TP53+	TC2	post_p					0.32 (0.13, 0.47)	0.35 (0.1, 0.48)	0.35 (0.15, 0.48)	0.34 (0.17, 0.47)					0.48 (0.43, 0.5)	0.45 (0.35, 0.5)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	r_prob					0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.25 (0.25, 0.25)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	rate					0.026 (0.018, 0.036)	0.026 (0.016, 0.047)	0.026 (0.019, 0.04)	0.028 (0.017, 0.053)					0.018 (0, 0.157)	0.032 (0, 0.08)	NA (NA, NA)	0 (0, 0.056)
TP53+	TC3	count					37	37	37	37					37	37	37	37
TP53+	TC3	time					41 (28, 52)	41 (28, 52)	41 (28, 52)	41 (28, 52)					41 (28, 52)	41 (28, 52)	41 (28, 52)	41 (28, 52)
TP53+	TC3	n					27 (12, 52)	14 (8, 27)	18 (7, 34)	13 (7, 27)					0 (0, 1)	3 (1, 6)	0 (0, 0)	0 (0, 0)
TP53+	TC3	post_p					0.35 (0.07, 0.48)	0.37 (0.16, 0.45)	0.39 (0.19, 0.48)	0.39 (0.2, 0.47)					0.46 (0.44, 0.48)	0.47 (0.27, 0.5)	NA (NA, NA)	0.43 (0.43, 0.43)
TP53+	TC3	r_prob					0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)					0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
TP53+	TC3	rate					0.024 (0.018, 0.039)	0.024 (0.019, 0.035)	0.023 (0.016, 0.039)	0.025 (0.017, 0.04)					0 (0, 0.096)	0.028 (0.013, 0.094)	NA (NA, NA)	0.027 (0.027, 0.027)
TEfus+	TC1	count			96	96			96	96			96	96			96	96
TEfus+	TC1	time			45 (32, 56)	45 (32, 56)			45 (32, 56)	45 (32, 56)			45 (32, 56)	45 (32, 56)			45 (32, 56)	45 (32, 56)
TEfus+	TC1	n			6 (2, 9)	17 (11, 32)			15 (8, 23)	11 (6, 22)			8 (5, 16)	2 (0, 5)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	post_p			0.4 (0.22, 0.49)	0.31 (0.07, 0.46)			0.34 (0.14, 0.49)	0.34 (0.13, 0.47)			0.36 (0.12, 0.48)	0.45 (0.35, 0.49)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC1	r_prob			0.18 (0.18, 0.18)	0.07 (0.07, 0.07)			0.12 (0.12, 0.12)	0.06 (0.06, 0.06)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	rate			0.03 (0.02, 0.062)	0.026 (0.018, 0.035)			0.026 (0.019, 0.04)	0.027 (0.02, 0.042)			0.03 (0.02, 0.052)	0.035 (0.014, 0.085)			NA (NA, NA)	0.045 (0.009, 0.081)
TEfus+	TC2	count			90	90			90	90			90	90			90	90
TEfus+	TC2	time			40 (28, 59)	40 (28, 59)			40 (28, 59)	40 (28, 59)			40 (28, 59)	40 (28, 59)			40 (28, 59)	40 (28, 59)
TEfus+	TC2	n			6 (3, 10)	16 (11, 30)			16 (8, 29)	10 (6, 21)			9 (5, 18)	2 (0, 6)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	post_p			0.42 (0.3, 0.48)	0.27 (0.09, 0.48)			0.33 (0.11, 0.47)	0.34 (0.15, 0.48)			0.39 (0.16, 0.49)	0.45 (0.37, 0.49)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC2	r_prob			0.41 (0.41, 0.41)	0.27 (0.27, 0.27)			0.41 (0.41, 0.41)	0.25 (0.25, 0.25)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	rate			0.029 (0.016, 0.042)	0.027 (0.018, 0.039)			0.027 (0.019, 0.041)	0.027 (0.018, 0.043)			0.031 (0.02, 0.056)	0.031 (0.014, 0.104)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC3	count			31	31			31	31			31	31			31	31
TEfus+	TC3	time			42 (33, 55)	42 (33, 55)			42 (33, 55)	42 (33, 55)			42 (33, 55)	42 (33, 55)			42 (33, 55)	42 (33, 55)
TEfus+	TC3	n			5 (2, 8)	19 (13, 42)			17 (8, 31)	11 (6, 29)			10 (5, 18)	3 (1, 6)			0 (0, 0)	0 (0, 0)
TEfus+	TC3	post_p			0.46 (0.28, 0.48)	0.36 (0.2, 0.48)			0.4 (0.23, 0.48)	0.38 (0.17, 0.49)			0.32 (0.19, 0.46)	0.46 (0.33, 0.48)			0.43 (0.43, 0.43)	NA (NA, NA)
TEfus+	TC3	r_prob			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.5 (0.5, 0.5)	0.33 (0.33, 0.33)			0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
TEfus+	TC3	rate			0.027 (0.018, 0.068)	0.023 (0.017, 0.029)			0.023 (0.018, 0.04)	0.027 (0.017, 0.043)			0.027 (0.018, 0.042)	0.026 (0, 0.056)			0.088 (0.088, 0.088)	NA (NA, NA)
PI3K+	TC1	count		144		144		144		144		144		144		144		144
PI3K+	TC1	time		42 (32, 54)		42 (32, 54)		42 (32, 54)		42 (32, 54)		42 (32, 54)		42 (32, 54)		42 (32, 54)		42 (32, 54)
PI3K+	TC1	n		13 (7, 22)		16 (9, 34)		14 (7, 27)		11 (6, 20)		0 (0, 0)		2 (0, 5)		3 (1, 7)		0 (0, 0)
PI3K+	TC1	post_p		0.3 (0.08, 0.45)		0.28 (0.11, 0.48)		0.29 (0.09, 0.47)		0.31 (0.08, 0.48)		NA (NA, NA)		0.45 (0.35, 0.5)		0.44 (0.32, 0.49)		NA (NA, NA)
PI3K+	TC1	r_prob		0.27 (0.27, 0.27)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.06 (0.06, 0.06)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	rate		0.027 (0.019, 0.045)		0.027 (0.019, 0.038)		0.027 (0.019, 0.048)		0.029 (0.019, 0.045)		NA (NA, NA)		0.033 (0.013, 0.091)		0.032 (0.016, 0.092)		0 (0, 0.079)
PI3K+	TC2	count		119		119		119		119		119		119		119		119
PI3K+	TC2	time		42 (28, 56)		42 (28, 56)		42 (28, 56)		42 (28, 56)		42 (28, 56)		42 (28, 56)		42 (28, 56)		42 (28, 56)
PI3K+	TC2	n		13 (7, 26)		16 (10, 30)		15 (8, 29)		11 (6, 21)		0 (0, 0)		2 (0, 5)		3 (0, 6)		0 (0, 0)
PI3K+	TC2	post_p		0.35 (0.12, 0.48)		0.27 (0.07, 0.43)		0.32 (0.07, 0.46)		0.33 (0.1, 0.46)		NA (NA, NA)		0.46 (0.36, 0.5)		0.45 (0.31, 0.49)		NA (NA, NA)
PI3K+	TC2	r_prob		0.07 (0.07, 0.07)		0.27 (0.27, 0.27)		0.27 (0.27, 0.27)		0.25 (0.25, 0.25)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	rate		0.026 (0.018, 0.045)		0.027 (0.018, 0.04)		0.027 (0.018, 0.046)		0.027 (0.019, 0.045)		0.085 (0.085, 0.085)		0.028 (0.001, 0.087)		0.031 (0, 0.075)		0 (0, 0)
PI3K+	TC3	count		45		45		45		45		45		45		45		45
PI3K+	TC3	time		40 (30, 54)		40 (30, 54)		40 (30, 54)		40 (30, 54)		40 (30, 54)		40 (30, 54)		40 (30, 54)		40 (30, 54)
PI3K+	TC3	n		12 (8, 26)		18 (9, 31)		15 (8, 30)		10 (5, 24)		0 (0, 0)		3 (1, 5)		4 (2, 6)		0 (0, 0)
PI3K+	TC3	post_p		0.37 (0.16, 0.47)		0.37 (0.12, 0.49)		0.31 (0.15, 0.47)		0.38 (0.22, 0.46)		NA (NA, NA)		0.44 (0.32, 0.49)		0.44 (0.29, 0.5)		NA (NA, NA)
PI3K+	TC3	r_prob		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC3	rate		0.026 (0.018, 0.038)		0.024 (0.017, 0.04)		0.026 (0.018, 0.041)		0.028 (0.018, 0.056)		NA (NA, NA)		0.034 (0.009, 0.091)		0.029 (0.016, 0.084)		0 (0, 0)